Case of bullous pemphigoid coexisting with anti‐desmoglein autoantibodies |
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| Authors: | Duerna Tie Tokiko Yoshida Yuko Chinuki Xia Da Noriyoshi Ishikawa Eishin Morita |
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| Institution: | 1. Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan;2. Department of Pathology, Shimane University Faculty of Medicine, Izumo, Japan |
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| Abstract: | A 79‐year‐old Japanese woman had clinical and histopathological features of bullous pemphigoid, while direct immunofluorescence test revealed C3 and immunoglobulin G depositions in the lower cell surfaces of the epidermis in addition to those in the dermoepidermal junction. Chemiluminescent enzyme immunoassays were positive for desmoglein‐1 and ‐3 antibodies in addition to anti‐BP180 antibodies. In an immunoblotting study, antibodies against both 180‐kDa bullous pemphigoid antigen and 130‐kDa pemphigus vulgaris antigen were detected. Based on these results, bullous pemphigoid coexisting with anti‐desmoglein autoantibodies was diagnosed in this case. |
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| Keywords: | anti‐BP180 antibodies anti‐desmoglein antibodies bullous pemphigoid immunoblotting pemphigus |
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