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| 茶多酚对D-半乳糖诱导衰老小鼠红细胞氧化损伤影响 | |
| 引用本文： | 王贞丽,陈雪红,王丽华,王春波.茶多酚对D-半乳糖诱导衰老小鼠红细胞氧化损伤影响[J].齐鲁医学杂志,2006,21(3):210-212. |
| 作者姓名： | 王贞丽 陈雪红 王丽华 王春波 |
| 作者单位： | 1. 中国人民解放军济南军区青岛第一疗养院药剂科,山东,青岛,266071 2. 青岛大学医学院药理学教研室 3. 青岛市妇女儿童医疗保健中心 |
| 摘 要： | 目的观察茶多酚对衰老小鼠红细胞氧化损伤的影响。方法对以D-半乳糖诱导衰老小鼠模型分别以低、中、高剂量的茶多酚灌胃30 d,测定小鼠红细胞超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量,红细胞膜Na -K -ATPase活性和唾液酸含量。结果模型组红细胞SOD活性、Na -K -ATPase活性和唾液酸含量与正常对照组比较显著下降,茶多酚给药组小鼠红细胞SOD活性、细胞膜Na -K -ATPase活性和唾液酸含量较正常对照组明显增高,MDA含量降低,在各给药组中以茶多酚大剂量组的作用最强。结论茶多酚能增强机体抗氧化能力,减少自由基对生物膜的损伤,维持细胞膜的稳定性,具有抗衰老作用。 |
| 关 键 词： | 茶多酚 衰老 红细胞 超氧化物歧化酶 丙二醛 |
| 文章编号： | 1008-0341(2006)03-0210-03 |
| 收稿时间： | 2005-08-22 |
| 修稿时间： | 2005-12-20 |
EFFECT OF TEA POLYPHENOL ON RED BLOOD CELLS OF AGING MICE INDUCED BY D-GALACTOSE |
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| WANG ZHEN LI, CHEN XUE-HONG, WANG LI HUA, et al.EFFECT OF TEA POLYPHENOL ON RED BLOOD CELLS OF AGING MICE INDUCED BY D-GALACTOSE[J].Medical Journal of Qilu,2006,21(3):210-212. | |
| Authors: | WANG ZHEN LI CHEN XUE-HONG WANG LI HUA |
| Abstract: | Objective To investigate the effect and mechanism of tea polyphenol on red blood cells(RBC) in aging mice. Methods The aging mice induced by D-galactose were given tea polyphenol at different doses for 30 days.The activity of SOD and the MDA content in RBC,the activity of Na~ -K~ -ATPase and content of acetylneuraminic acid in RBC membrane were detected.Results Comparing with normal control group,the activity of SOD,Na~ -K~ -ATPase and the content of acetylneuraminic acid in model group declined;the activity of SOD and Na~ -K~ -ATPase,the content of acetylneuraminic acid elevated,but the amount of MDA declined.The optimal action of tea polyphenol appeared in high-dose group. Conclusion Tea polyphenol can enhance the antioxidant ability human body,reduce the damage of free radical to cell membrane,maintain the stability of cell membrane and it has antiaging effect. |
| Keywords: | tea polyphenol aging erythrocytes superoxide dismutase malondiadehyde |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |