| 老年人自然免疫状态下抗肺炎链球菌抗体的检测 |
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| 引用本文： | 陈许,张洁,黄瑾.老年人自然免疫状态下抗肺炎链球菌抗体的检测[J].中国误诊学杂志,2011,11(32):7819-7822. |
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| 作者姓名： | 陈许 张洁 黄瑾 |
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| 作者单位： | 1. 中山大学附属第五医院呼吸内科,广东珠海,519000
2. 中山大学附属第五医院影像科,广东珠海,519000 |
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| 摘 要： | 目的 探讨自然免疫状态下血清抗肺炎链球菌荚膜多糖特异性抗体值,为老年人是否需常规使用PPV23免疫提供参考.方法 健康人85例(健康组),分为青年、中年、老年组；老年COPD患者18例(C()PD组),ELISA检测血清特异性抗体.结果健康组:IgA老年组同中、青年组差异无统计学意义；IgM青年组高于其他两组(P＜0.05)；总IgG差异无统计学意义,IgG4老年及中年组高于青年组(P＜0.05).IgM浓度与年龄负相关(r=-0.274,P＜0.05),IgG4与年龄正相关(r=0.342,P＜0.05).COPD组和健康老年人组差异无统计学意义.结论 未发现健康及COPD老年人血清抗肺炎链球菌保护性抗体整体水平低下,不支持该人群常规使用PPV23.
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| 关 键 词： | 肺炎链球菌荚膜多糖 疫苗 抗体 老年人 慢性阻塞性肺疾病 |
Streptococcus pneumoniae capsular polysaccharide antibodies of old people in naturally acquired active immunity |
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| CHEN Xu,ZHANG Jie,HUANG Jin.Streptococcus pneumoniae capsular polysaccharide antibodies of old people in naturally acquired active immunity[J].Chinese Journal of Misdiagnostics,2011,11(32):7819-7822. |
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| Authors: | CHEN Xu ZHANG Jie HUANG Jin |
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| Institution: | CHEN Xu,ZHANG Jie,HUANG Jin Department of Respiratory Medicine,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China |
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| Abstract: | Objective To explore the necessary for elderly individuals to immunize with pneumococcal vaccine polyvalent,antibodies of several isotypes and subclasses that specific to streptococcus pneumoniae capsular polysaccharide(CPS) in serum.Methods The specific antibodies in serum were measured in 85 health adults and 18 elderly patients with chronic obstructive pulmonary disease(COPD) by indirect Enzyme Linked Immunosorbent Assay(ELISA).Results The health adults were split into aged,meddle-aged and young groups.T... |
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| Keywords: | streptococcus pneumoniae capsular polysaccharide vaccine older adults COPD antibody |
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