糖尿病肾病微血管病变的彩色多普勒血流显像研究

目的 观察糖尿病肾病(DN)肾脏局部血流动力学的变化情况,探讨彩色多普勒血流显像(CDFI)在DN诊疗中的临床应用价值.方法 应用CDFI检测35例肾功能不全期DN组和年龄匹配的35例临床DN期组肾脏弓状动脉血流动力学变化的各项参数,并与30例对照组对比分析.结果 肾功能不全期DN组患者搏动指数和阻力指数高于临床DN期组患者(P<0.01或P<0.05),收缩期峰值流速、平均流速低于临床DN期组(P<0.05或P<0.01).与对照组比较,肾功能不全期DN组和临床DN组的搏动指数、阻力指数明显增高(P<0.01),肾功能不全期DN组舒张末期流速和平均流速明显降低(P<0.01),临床DN期组收缩期峰值流速增高(P<0.05),舒张末期流速降低(P<0.05).结论 CDFI是评价DN肾脏局部的血流动力学变化的有效方法,在预测肾脏损害和判断肾功能不全方面有一定价值.

Study of color doppler flow imaging in diabetic nephropathy

Objective To observe the changes of renal hemodynamics in diabetes mellitus with diabetic nephropathy(DN) with color Doppler flow imaging(CDFI). Methods The renal hemodynamics of arcuate artery flow were studied with CDFI in 35 patients with diabetic renal failure among age matched 35 cases of clinical DN and 30 cases of normal volunteers. Results The pulsative index and resistance index of the patients with diabetic renal failure were significantly higher and the systole peak velocity and mean velocity were lower than those of clinical DN. Compared with normal controls, the PI and RI in the patients with clinical DN or diabetic renal failure were greatly increased. The end-diastolic velocity of blood flow and the mean velocity were significantly reduced in the patients with diabetic renal failure. The peak velocity of blood flow during systole was increased and the end-diastolic velocity of blood flow was reduced in the patients with clinical DN. Conclusion CDFI is an effective method in evaluation of renal hemodynamics in DN, and CDFI might be valuable for forecasting the renal injury and judging the renal failure.