血小板增多、血管内皮生长因子在老年胃癌中表达及预后

目的:研究血小板增多、血管内皮生长因子VEGF表达与老年胃癌预后关系。方法:回顾分析了92 例老年胃癌患者血小板增多、VEGF表达情况,并分析它们与胃癌临床病理特征关系及对预后影响。结果:胃癌患 者血小板增多发生率为28.26%,VEGF蛋白表达阳性率为66.7%,并且二者表达呈正相关(P<0.01)。血小板增 多、VEGF表达与肿瘤大小、浸润深度、淋巴结转移、TNM分期、血管癌栓密切相关(P<0.01),血小板增多、VEGF阳 性表达与胃癌预后呈负相关。结论:血小板增多与VEGF表达密切相关,二者与胃癌生长、浸润关系密切,可作为 估计老年胃癌预后的重要因素。

Poor prognosis associated with thrombocytosis and vascular endothelial growth factor expression in aged patients with gastric carcinoma

Objective:To investigate the thrombocytosis and vascular endothelial growth factor(VEGF)expression and their influence on clinicopathological characteristics and the prognosis in aged patients with gastric carcinoma.Methods:Expression of VEGF was examined with immunohistochemical technique and platelet count and clinicopathlogical factors were reviewed in 92 cases gastric carcinoma patients.Results:Thrombocytosis was found in 26 patients(28.26%)and expression of VEGF was observed in 66.7% of gastric carcinoma,A significant correlation was found between thrombocyosis and VEGF .The expression of VEGF and thrombocytosis were related to the tumour size,depth,lymph node metastasis,vessel invasion and TNM stage(P<0.01),The prognosis of patients with thrombocytosis and expression of VEGF was poor. Conclusion:Thrombocytosis and overexpression of VEGF in gastric carcinoma enhance the possibility of invasion and metastasis and implicate a poor prognosis.