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Anomalous origin of the left main pulmonary artery from the ascending aorta associated with Digeorge syndrome |
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| Authors: | Hidemi Dodo MD Juan C Alejos MD Joseph K Perloff MD Hillel Laks MD Davis C Drinkwater MD Roberta G Williams MD |
| Institution: | aFrom the Departments of Pediatrics, Medicine, and Surgery, Divisions of Medical and Pediatric Cardiology, and Cardiothoracic SurgeryU.S.A. bFrom the UCLA Adult Congenital Heart Disease Center, University of California, Los Angeles, California U.S.A. |
| Abstract: | We place on record 2 infants with the DiGeorge syndrome and anomalous origin of the left pulmonary artery from the ascending aorta. We postulate that: (1) embryogenesis of anomalous origin of the left pulmonary artery from the ascending aorta might be due to the persistent fifth aortic arch connecting both arterial systems; (2) an anomalous pulmonary artery arising from the ascending aorta is part of the aortic arch abnormality accompanied by normal conotruncal septation; and (3) in the DiGeorge syndrome, cardiac anomalies that originate from the conotruncus or aortic arch, or both, may have the same embryologic mechanisms. |
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