| Survivin蛋白在食管鳞状细胞癌中的表达及意义 |
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| 引用本文： | 刘杰,刁路民.Survivin蛋白在食管鳞状细胞癌中的表达及意义[J].郧阳医学院学报,2010,29(1):43-44,47. |
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| 作者姓名： | 刘杰 刁路民 |
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| 作者单位： | 刘杰(武汉大学基础医学院病理学教研室,湖北,武汉 430071;郧阳医学院附属人民医院重症医学科,湖北 十堰 442000);刁路民(郧阳医学院附属人民医院重症医学科,湖北 十堰,442000) |
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| 摘 要： | 目的:探讨Survivin蛋白在食管鳞状细胞癌中的表达和临床意义。方法:S-P法检测86例食管鳞癌标本及其癌旁组织Survivin蛋白表达情况,研究其与食管鳞癌临床病理特征之间的关系。结果:Survivin蛋白主要位于肿瘤细胞胞质,在食管鳞癌组织阳性表达率为75.5%(65/86),癌旁组织中不表达,其表达与淋巴结转移密切相关(P<0.05),与鳞癌分化程度无关(P>0.05)。结论:Survivin表达可能与食管鳞癌的发生、发展及淋巴结转移密切相关,其表达水平可以作为判断食管癌恶性潜能的重要生物学指标。
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| 关 键 词： | Survivin 食管 鳞状细胞癌 |
Expression and Significance of Survivin in Human Esophageal Squamous Cell Carcinoma |
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| LIU Jie,DIAO Lu-min.Expression and Significance of Survivin in Human Esophageal Squamous Cell Carcinoma[J].Journal of Yunyang Medical College,2010,29(1):43-44,47. |
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| Authors: | LIU Jie DIAO Lu-min |
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| Institution: | LIU Jie1,2,DIAO Lu-min2 (1Department of Pathology,Faculty of Basic Medicine Science,Wuhan University,Wuhan,Hubei 430071,2Department of Intensive Care Unit,Renmin Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China) |
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| Abstract: | Objective To investigate the expression of survivin in esophageal squamous cell carcinoma and its clinical significance.Methods The expression of survivin in 86 cases of esophageal squamous carcinoma and adjacent normal esophageal tissues were determined with S-P method,and then its relationship with clinical pathology was analyzed.Results Survivin protein was mainly in cytoplasmic and the positive expression rate was 75.5%(65/86),but it had no expression in adjacent tissues.The expression of survivin was c... |
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| Keywords: | Survivin |
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