MBP、抗神经节苷脂抗体与格林-巴利综合征亚型及严重度相关性分析

目的：通过检测格林-巴利综合征（GBS）患者血清麦芽糖结合蛋白（MBP）和抗神经节苷脂抗体水平，探讨其与格林-巴利综合征亚型及严重度的相关性。方法选用2009年3月至2012年3月在我院治疗的格林-巴利综合征患者90例作为观察组，选取同期其他神经系统疾病患者90例作为对照1组和健康体检者100例作为对照2组。采用酶联免疫吸附法（ELISA）检测三组受试者的血清MBP和抗神经节苷脂抗体水平，并进行对比分析。结果（1）观察组血清MBP水平、抗神经节苷脂抗体阳性率均显著高于对照1组和对照2组，其差异均有统计学意义（P〈0.05）；对照1组血清中MBP水平显著高于对照2组，两组MBP差异具有统计学意义（P〈0.05）。（2）急性炎性脱髓鞘性多发性神经根神经病（AIDP）患者血清MBP水平与急性运动轴索型神经病（AMAN）、急性运动感觉轴索型神经病（AMSAN）及米勒费雪症候群（MFS）比较差异均无统计学意义（P〉0.05）；AIDP患者血清抗神经节苷脂抗体阳性率显著高于AMAN、AMSAN及MFS ，其差异均有统计学意义（P〈0.05）。（3）病情等级越高GBS患者血清中MBP水平、抗神经节苷脂抗体阳性率越高，不同等级间的差异均有统计学意义（P〈0.05）。结论 MBP、抗神经节苷脂抗体与格林-巴利综合征严重度呈正相关，抗神经节苷脂抗体可能与格林-巴利综合征亚型AIDP相关。

Correlation analysis of MBP,anti-ganglioside antibodies and the severity of Guillain-Barre syndrome subtype

Objective To explore the correlation of maltose binding protein （MBP）, anti-ganglioside antibodies and Guillain-Barre syndrome subtype＆#39;s severity by detecting serum levels of MBP, anti-ganglioside antibodies in patients with Guillain-Barre syndrome （GBS）. Methods Ninety patients with Guillain-Barre syndrome in our hospital from March 2009 to March 2012 were selected as observation group, and 90 patients with neurological diseases were selected as control group 1 and 100 healthy people were chosen as control group 2 at the same time. Then enzyme-linked immunosorbent assay （ELISA） was used to test the serum levels of MBP and anti-ganglioside antibody in three groups. The results obtained were compared at last. Results （1） The MBP and anti-ganglioside antibodies levels in the observation group were significantly higher than those in the control group 1 and control group 2 （P〈0.05）. The MBP levels in the control group 1 was significantly higher than those in the control group 2 with a statistically significant difference （P〈0.05）. （2） There was no difference in the serum MBP level between patients with AIDP and patients with AMAN, AMSAN or MFS （P〉0.05）. However, the positive rates of serum anti-ganglioside antibodies in patients with AIDP was significantly higher than those in patients with AMAN, AMSAN or MFS with statistically signif-icant differences （P〈0.05）. （3） The severity of GBS was positive related with the positive rate of MBP and the levels of anti-ganglioside antibodies. Conclusion There is a positive correlation between MBP, anti-ganglioside antibodies and the severity of Guillain-Barre syndrome, and the anti-ganglioside antibodies may be associated with Guil-lain-Barre syndrome subtypes-AIDP.