| The Expression of TNF-α and ICAM-1 in Lesions of Lichen Planus and Its Implication |
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| 引用本文： | 陈旭娥,刘志香,岳青,刘厚君,吴艳,李家文.The Expression of TNF-α and ICAM-1 in Lesions of Lichen Planus and Its Implication[J].华中科技大学学报(医学英德文版),2007,27(6):739-741. |
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| 作者姓名： | 陈旭娥 刘志香 岳青 刘厚君 吴艳 李家文 |
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| 作者单位： | Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science Technology，Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science Technology，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China，Wuhan 430022 China |
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| 摘 要： | In order to investigate the role of TNF-α and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-α and ICAM-1 in skin le- sions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-α and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the in- crease of TNF-α and that of ICAM-1 in lichen planus. The expression of TNF-α and ICAM-1 might play an important role in the development of lichen planus.
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| 关 键 词： | TNF-α ICAM-1 lichen planus |
| 收稿时间： | 2007-10-16 |
The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication |
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| Chen Xu’e,Liu Zhixiang,Yue Qing,Liu Houjun,Wu Yan,Li Jiawen.The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2007,27(6):739-741. |
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| Authors: | Chen Xu’e Liu Zhixiang Yue Qing Liu Houjun Wu Yan Li Jiawen |
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| Institution: | Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science Technology, Wuhan, 430022, China. CXE911@hotmail.com |
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| Abstract: | In order to investigate the role of TNF-and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-alpha and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of TNF-alpha and that of ICAM-1 in lichen planus. The expression of TNF-alpha and ICAM-1 might play an important role in the development of lichen planus. |
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