| 参麦注射液防治兔油酸型急性呼吸窘迫综合征的实验研究 |
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| 引用本文： | 沈炳玲,李国.参麦注射液防治兔油酸型急性呼吸窘迫综合征的实验研究[J].天津医科大学学报,1999,5(1):35-38. |
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| 作者姓名： | 沈炳玲 李国 |
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| 作者单位： | 天津医科大学病生理教研室，天津市脑系科医院 |
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| 摘 要： | 目的：观察静注参麦注射液对实验性油酸型急性呼吸窘迫综合征（ＡＲＤＳ）的影响。方法：静脉注射油酸（０．１ｍｌ／ｋｇ）复制家兔ＡＲＤＳ的动物模型，随后立即静脉注射参麦注射液（１０ｍｌ／ｋｇ），观察在ＡＲＤＳ发展过程中白细胞介素－１（ＩＬ－１）、肿瘤坏死因子（ＴＮＦ）、血气，２ｈ后处死动物检测肺组织匀浆ＩＬ－１、ＴＮＦ活性及病理改变，并与模型组做比较。结果：参麦注射液可明显缓解油酸所致的急性肺损伤，改善低氧血症，经统计学处理后治疗组与模型组相比，血浆ＩＬ－１，ＴＮＦ在１２０ｍｉｎ（Ｐ＜０．０５），肺组织匀浆ＩＬ－１、ＴＮＦ治疗组与模型组相比较亦降低（Ｐ＜０．０５）。结论：提示参麦注射液可明显减轻所致的急性肺损伤，对防治ＡＲＤＳ有一定的作用
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| 关 键 词： | 参麦注射液 油酸 实验性呼吸窘迫综合征 |
EXPERMENTAL STUDY OF EFFECT OF SHEN MAI INJECTION ON ACTUE RESPRIATORY DISTRESS SYNDROME BY OLEIC ACID IN RABBITS |
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| Shen Bingling,Qi Hong,Li Guo,et al.EXPERMENTAL STUDY OF EFFECT OF SHEN MAI INJECTION ON ACTUE RESPRIATORY DISTRESS SYNDROME BY OLEIC ACID IN RABBITS[J].Journal of Tianjin Medical University,1999,5(1):35-38. |
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| Authors: | Shen Bingling Qi Hong Li Guo |
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| Abstract: | Objective:To observe the effect of Shen-Mai injection on experimental acute respiratory distress syndrome (ARDS) induced by oleic acid Methods:ARDS animal model was prepared in rabbits by iv oleic acid (0 1ml/kg), then iv Shen-Mai injection (10ml/kg) and plasma interleukin-1 (IL-1), tumor necrerosis factor (TNF) activity in different time points and pathologic changes were observed and compared to control group Results:The acute lung injury induced by oleic acid was decresed; hypoxemia was improved; the IL-1 and TNF activity in plasma and lung tissue homogenates were decresed in treatment group, it was superior to those in oleic acid group ( P <0 05) Conclusion:Shen-Mai injection can alleviate the acute lung injury induced by oleic acid, so it has some action on preventing and treating experimental ARDS |
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| Keywords: | Shen Mai Injection Oleic acid Experimental ARDS |
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