经典1型糖尿病肾病患者血浆脂联素水平变化的探讨

目的研究脂联素与经典1型糖尿病肾病发生发展的关系。方法正常对照组15例和45例经典1型糖尿病患者血清脂联素水平、血尿素氮和血清肌酐和尿白蛋白排泄率。根据尿白蛋白排泄率(UAER)将糖尿病患者分为3组:单纯DM组(SDM组);早期DN组(EDN组);临床期DN组(CDN组)。EDN组和CDN组可合称为DN组。结果 SDM组血清脂联素水平较对照组显著升高(P<0.05);CDN组血清脂联素水平较NC组、SDM组、EDN组显著升高均。DN组血清脂联素水平较SDM组显著升高(P<0.05)。血清脂联素水平与UAER呈显著正相关(r=0.598,P<0.01):及肾小球滤过率显著独立负相关(r=0.-208,P<0.05),与年龄正相关(r=0.158,P<0.05);与病程正相关(r=0.161,P<0.05);与BMI、WHR呈显著负相关(r分别为-0.169和-0.202,均P<0.05)。结论经典1型糖尿病病人中,血脂联素水平与尿白蛋白排泄率(UAER)密切相关。

Relation between Serum Levels of Adiponectin and Diabeticnephropathy in Type 1 Diabetes Mellitus

Objective To analyze t he relationship between serum levels of adiponectin and renal function in type 1 diabetes mellitus.Methods Clinical history of 45 cases of type 1 diabetes mellitus were reviewed.Results(1)Plasma adiponectin concentrations were significantly higher in diabetic subjects than in control subjects(p<0.05).Further,serum adiponectin was higher in patients with than in those without nephropathy(p<0.05).(2)There were positive correlations between adiponectin and age,duration,and UAER.There were inverse correlations between adiponectin and BMI,WHR,and glomerular filtration rate.Conclusion Increased adiponectin level is observed in type 1 diabetic patients and is positively associated with impairment of renal function.