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HLA Antigens and Adult T-Cell Leukemia Virus Infection: A Community-Based Study in the Goto Islands, Japan |
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| Authors: | TAJIMA, KAZUO AKAZA, TATSUYA KOICHI, KOIKE HINUMA, YORIO SUCHI, TAIZAN TOMINAGA, SUKETAMI |
| Affiliation: | Division of Epidemiology, Aichi Cancer Center Research Institute 1Department of Transplantation, Nagoya Second Red Cross Hospital Nagoya 2Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital Nagoya 3Institute for Virus Research, Kyoto University Kyoto |
| Abstract: | In order to study the genetical susceptibility to infectionby adult T-cell leukemia virus (ATLV), which is considered tobe a main causative agent of adult T-cell leukemia (ATL), theHLA profile of persons with antibody against ATLV-associatedantigen (anti-ATLA) was compared with that of antibody-negativepersons in villages A and B of the Goto Islands, a typical ATLendemic area in Kyushu, Japan. The frequency (29%) of HLA-B7in persons with anti-ATLA was significantly higher than that(8%) in anti-ATLA negatives (corrected X2=7.73, p<0.01) inone village while the frequency of HLA-B7 was around 10% inboth positive and negative persons in the other village. Theseresults do not support or deny the possibility of the existenceof individuals who are genetically susceptible to ATLV infectionin ATL endemic areas of Japan. |
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