Viral susceptibility of an immortalized human microvascular endothelial cell line. |
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Authors: | E W Ades J C Hierholzer V George J Black F Candal |
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Affiliation: | Biological Products Branch, Centers for Disease Control, Atlanta, Georgia 30333. |
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Abstract: | CDC/EU.HMEC-1 is the first immortalized human microvascular endothelial cell line that retains morphologic, phenotypic, and functional characteristics of a normal human microvascular endothelial cell. This study evaluates a variety of viruses and their effects on this human endothelial cell line. The data indicate that adenoviruses, some herpesviruses, reoviruses and most picornaviruses grow well in HMEC-1, with distinctive cytopathic effects. The paramyxoviruses, however, do not appear to propagate, nor does HIV. The findings indicate that microvascular endothelial cells may act as a reservoir of these viruses; it also suggests the possibility that microvascular endothelium could be involved in the processing and presentation of antigen to immune cells. |
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