Effects of ruthenium red and KCL on responses of guinea pig umbilical veins. |
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Authors: | X Nair E L Watson J H Luft |
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Institution: | Departments of Pharmacology and Biological Structure, School of Medicine, University of Washington, Seattle, Wa. 98195, U.S.A. |
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Abstract: | 5-Hydroxytryptamine (10(-5) M), norepinephrine (10(-5) M) and acetylcholine (10(-5) M) induced maximal contractions in isolated guinea pig umbilical vein strips. Pretreatment with ruthenium red (2.7--90 mug/ml) for ten minutes reduced 5-hydroxytryptamine and norepinephrine responses in a dose-related manner but did not affect acetylcholine-induced responses. Ruthenium red alone did not produce contractions. In the presence of KC1 (125 MM) the responses to norepinephrine and acetylcholine were enhanced significantly. The sensitivity of umbilical veins to ruthenium red may be useful in determining to what extent various vasoactive agents utilize extracellular calcium to induce contractions. |
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Keywords: | Umbilical veins Norepinephrine Acetylcholine Ruthenium red 5-Hydroxytryptamine |
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