瓜氨酸合成蛋白抗体、抗RA33抗体检测在类风湿关节炎诊断中的应用

目的 探讨瓜氨酸合成蛋白抗体（CPA）和抗RA33抗体检测在类风湿关节炎（RA）诊断中的意义。方法 用ELISA法分别检测94例RA和97例非RA风湿病患者血清中的CPA、抗RA33抗体和类风湿因子（RF）水平。结果 CPA、抗RA33抗体和RF对RA诊断的敏感性分别为73．4％、31．9％和72．3％；特异性分别为96．9％、75．3％和77．3％CPA与抗RA33抗体或RF联合可提高诊断的特异性；CPA和RF滴度呈正相关。结论 CPA对RA的诊断有良好的特异性和敏感性，较抗RA33抗体和RF为优，可作为RA诊断的血清学指标，与RF联合检测效果最佳。

Diagnostic value of citrullinated protein antibody and anti-RA33 antibody in patients with rheumatoid arthritis

Objective To explore the significance of citrullinated protein antibody (CPA) and anti-RA_ 33 antibody in the diagnosis of rheumatoid arthritis(RA).Methods CPA and anti- RA_ 33 antibody and rheumatoid factor (RF) were detected by ELISA assay in 94 patients with RA and 97 cases with rheumatic disease other than RA. Results The sensitivities in RA diagnosis of CPA,anti- RA_ 33 antibody and RF were 73.4%,31.9% and 72.3%,and the specificities were 96.9%,75.3% and 77.3%,respectively. CPA combined with either anti- RA_ 33 antibody or RF could increase the specificity of diagnosis. The quantity of CPA was positively correlated with that of RF. Conclusion CPA diagnostic specificity and sensitivity in RA are better than either anti-RA_ 33 antibody or RF,and could be regarded as a diagnostic marker in RA,better combined with RF. [