多发性硬化的MRI研究进展

多发性硬化（MS）是一种以中枢神经系统白质内多发脱髓鞘病灶与病程反复、交替缓解复发为主要特点的神经退行性疾病。MS临床表现具有非特异性，且常规MRI对其诊断有一定限度，而多种MRI新技术可以从影像上发现MS微小病灶、灰质病灶、软脑膜炎性反应，甚至可以探测表观正常的灰白质改变，对揭示MS病程演变中不同病理特征的改变、预测神经功能、行为改变等具有重要意义。就双反转恢复（DIR）成像、相位差强化成像（PADRE）、对比增强液体衰减反转恢复（CE-FLAIR）成像、MR波谱成像、扩散张量成像、功能MRI等新技术在MS中的应用进展作一概述。

The research advances in MR imaging of multiple sclerosis

Multiplesclerosis(MS)isaneurodegenerativediseasethatischaracterizedbymultifocaldemyelinatinglesionsmainlyinwhitemattersofcentralnervoussystemandrepeatedattackwithalternatedremissionandrelapsing.ClinicalmanifestationsofMSarequiteunspecificandconventionalMRIhasitslimitationindiagnosisofMS.While,manynewMRItechniquesmayhelptodetectminor/corticallesions,inflammationofleptomeninges,andevenchangesofnormal-appearingbrainparenchyma,whichmaycontributesignificantlyinrevealingchangesofdifferentpathologicalfeaturesduringdiseasecourses,predictingneuro-functionsandbehavioralchanges.Thispapersummarizestheprogressesinapplicationofdoubleinversion-recovery(DIR)imaging,phasedifference-enhancedimaging(PADRE),contrastenhancedfluid-attenuatedinversionrecovery(CE-FLAIR)imaging,magneticresonancespectroscopy(MRS),diffusiontensorimaging(DTI),andfunctionalMRItechniquesinMS.