中国帕金森病患者不宁腿综合征患病率的meta分析

目的为了研究不宁腿综合征(RLS)在中国帕金森病(PD)患者中的患病率,以及其与一般人群中RLS患病率的比较。方法通过在万方医学网、中国知网(CNKI)、维普网、Pubmed和Web of Science数据库中检索关于中国PD患者RLS的患病率相关的横断面研究和病例﹣对照研究。经过筛选后的文献采用Stata 12.0来分析RLS在中国PD患者中的患病率。结果总共纳入了34项研究,其中按照诊断标准可分为IRLSSG组(n=7)、NMS问卷组(n=16)、PDSS组(n=4)以及自定标准的其他组(n=7)。meta分析结果提示,总的RLS患病率为33%;IRLSSG组RLS的患病率为23%;NMS问卷组的患病率为44%;PDSS组为13%;其他组为28%。RLS在PD组的患病率明显高于一般人群(OR=4.65,95%CI:2.39~9.03,P0.001)。结论 RLS在中国PD人群中的患病率为33%;依据不同的诊断标准得出的患病率有所差异。NMS问卷作为RLS的初筛具有一定作用,而对于PD中RLS患者的诊断则推荐采用IRLSSG。此外,中国PD人群中的RLS患病率要明显高于一般人群。

Prevalence of restless legs syndrome among patients with Parkinson's disease in China: a meta-analysis

Objective To explore the prevalence of restless legs syndrome (RLS) in patients with Parkinson's disease (PD) in China, and to compare the prevalence of RLS between PD patients and the general population.Methods The cross-sectional and case-control studies on the prevalence of RLS among PD patients in China were collected by a computerized search of Wanfang Data, CNKI, VIP, PubMed, and Web of Science. Eligible studies were used for the analysis of the prevalence of RLS among PD patients in China by Stata 12.0.Results A total 34 studies were enrolled and divided into IRLSSG group (n=7), NMS group (n=16), PDSS group (n=4), and other group (n=7) based on diagnostic criteria. According to the results of the meta-analysis, the prevalence rates of RLS among PD patients in all the studies, the IRLSSG group, the NMS group, the PDSS group, and the other group were 33%, 23%, 44%, 13%, and 28%, respectively. The prevalence of RLS was significantly higher in PD patients than in the general population (odds ratio=4.65, 95% confidence interval:2.39-9.03, P<0.001).Conclusions The prevalence of RLS among PD patients in China is 33%, which varies due to different diagnostic criteria. NMS is an effective approach for initial screening for RLS. IRLSSG is recommended for the diagnosis of RLS in PD patients. The prevalence of RLS is significantly higher in PD patients than in the general population in China.