颞叶癫痫患者情绪及认知功能研究

目的调查颞叶癫痫(TLE)患者情绪及认知功能状况,分析相关的临床影响因素。方法对30例颞叶癫痫患者以及30例年龄、性别和受教育程度无差异的健康对照进行信息采集、神经心理学量表调查和统计学分析。结果与对照组相比,TLE组中出现焦虑情绪个体比例更高(P0.01);MoCA、WAIS-RC知识、TMT_B以及BDST评分较低,差异具有统计学意义(P0.05)。病程、癫痫家族史与MoCA评分及起病年龄与WAIS-RC知识评分之间均具有线性回归关系(决定系数分别为R~2=0.325和R~2=0.137,P0.05)。结论 TLE患者群体相较于正常人群更容易出现焦虑情绪,并且可出现整体智能、短时记忆、远期记忆能力、注意力和执行控制能力下降。对TLE患者,尤其对病程长、起病早和有家族史的患者,早期进行神经心理学评估将有利于及早发现认知功能损伤,实行有效干预。

A study of emotion and cognitive function in patients with temporal lobe epilepsy

Objective To investigate the emotional and cognitive status of patients with temporal lobe epilepsy (TLE) and analyze the influencing factors.Methods Thirty patients with TLE and 30 healthy controls matched for age, sex, and education level were enrolled for information collection, neuropsychological scale test, and statistical analysis.Results Compared with the control group, the TLE group had a significantly higher proportion of individuals experiencing anxiety (P<0.01) and significantly lower Montreal Cognitive Assessment (MoCA), Wechsler Adult Intelligence Scale Revised in China (WAIS-RC-knowledge), Trail Making Test (TMT_B), and Backward Digit Span Test (BDST) scores (P<0.05). There was a linear regression relationship between duration of seizures/family history of epilepsy and MoCA score and between age of onset and WAIS-RC-knowledge score (R²=0.325 and 0.137, respectively, both P<0.05).Conclusions Compared with normal people, patients with TLE are more prone to experience anxiety, and may have reduced overall intelligence, short-term memory, long-term memory, attention, and executive functioning. For patients with TLE, especially those with long disease duration, early onset, or family history, an early neuropsychological assessment will help with early detection of cognitive impairment and effective intervention.