| 2型糖尿病大血管病变与血液流变学改变和胰岛素抵抗关系的相关性 |
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| 引用本文： | 张燕,RONG Lin-jing. 2型糖尿病大血管病变与血液流变学改变和胰岛素抵抗关系的相关性[J]. 中国现代医学杂志, 2008, 18(14) |
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| 作者姓名： | 张燕 RONG Lin-jing |
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| 作者单位： | 广东省农垦中心医院,内分泌科,广东,湛江,524002 |
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| 摘 要： | 目的研究血液流变学变化和胰岛素抵抗（IR）与2型糖尿病（DM）大血管病变的关系。方法检测108例2型DM患者，其中有大血管并发症54例，无大血管并发症54例，以及54例正常对照组的血液流变学、空腹血糖（FBG）、空腹胰岛素（INS），计算胰岛素敏感性指数（IAI），并进行了比较。结果DM两组血黏度显著高于正常对照组；IAI显著低于正常对照组（P〈O．01）。DM有大血管病变组血黏度显著高于无大血管病变组；IAI显著低于无大血管病变组（P〈O．01）。多元逐步回归分析显示，2型DM大血管病变与DM病程、血糖、血黏度呈显著正相关，与IAI呈显著负相关。结论2型DM大血管病变患者存在严重的持续性高血黏、高血糖。DM病程的延长、严重的IR为2型DM大血管病变的主要危险因素。
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| 关 键 词： | 糖尿病 2型 大血管病变 血液流变学 胰岛素抵抗 |
Relationship of hemorheology changes, insulin resistance and macroangiopathy in type 2 diabetes |
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| ZHANG Yan,RONG Lin-jing. Relationship of hemorheology changes, insulin resistance and macroangiopathy in type 2 diabetes[J]. China Journal of Modern Medicine, 2008, 18(14) |
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| Authors: | ZHANG Yan RONG Lin-jing |
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| Affiliation: | ZHANG Yan,RONG Lin-jing (Department of Endocrinology,Nongken Centre Hospital of Guangdong,Zhanjiang,Guangdong 524002,P.R.China) |
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| Abstract: | [Objective] To investigate the relationship of hemorheology changes, insulin resistance(IR) and macrovascular complications in type 2 diabetes.[Methods]108 cases of type 2 diabetes (including 54 with macrovascular complications and 54 without macrovascular complications) and 54 healthy objects were observed. Hemorheology and fasting serum glucose(FBG), insulin were determined. Insulin sensitivity indexes (IAI) were calculated in all the objects. [Results] Viscosity in both type 2 diabetes groups were signif... |
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| Keywords: | diabetes mellitus type 2 macrovascular complications hemorheology insulin resistance |
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