| 降钙素基因相关肽对脑缺血大鼠脑血流的影响 |
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| 引用本文： | 王福庄 丁爱石. 降钙素基因相关肽对脑缺血大鼠脑血流的影响[J]. 中国病理生理杂志, 1994, 10(5): 473-476 |
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| 作者姓名： | 王福庄 丁爱石 |
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| 作者单位： | 北京军事医学科学院基础医学研究所，北京医科大学心肺内分泌研究室 |
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| 摘 要： | 大鼠侧脑室注入降钙素基因相关肽（ＣＧＲＰ）或等体积甘露醇为对照，用非损伤阻抗法测定一侧颈总动脉结扎后ＣＧＲＰ对脑血流的影响。结果表明，一侧颈总动脉结扎后，脑血流量降低３４％，此时侧脑室给予ＣＧＲＰ即刻使脑血流图波幅增加，５分钟时达高峰，比注药前平均增加６５％，与甘露醇对照相比差别非常显著（Ｐ＜０．０１），４０分钟时作用开始减弱，１００分钟后作用消失。与颈总动脉结扎前相比，在脑血供不足时，ＣＧＲＰ增
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| 关 键 词： | 降钙素 基因相关肽 脑缺血 大鼠 肽 动物模型 |
Effect of CGRP on Cerebral blood flow in the rat with cerebral ischemia |
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| Wang Fu-Zhuang,Ding Ai-Shi,et al Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing. Effect of CGRP on Cerebral blood flow in the rat with cerebral ischemia[J]. Chinese Journal of Pathophysiology, 1994, 10(5): 473-476 |
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| Authors: | Wang Fu-Zhuang Ding Ai-Shi et al Institute of Basic Medical Sciences Academy of Military Medical Sciences Beijing |
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| Abstract: | Rheoencephalogram were perfomed following intracerebroventricular infusionof calcitonin gene-related peptide in the rats with cerebral ischemia produced by ligation ofcarotid artery in one side.It was found that cerebral blood flow(CBF)decreased immedia-tely after ligation of carotid artery,and under cerebral ischemia CGRP obviously increasedCBF for nearly one hour. The increased of CBF caused by CGRP was greater in the ratswith cerebral ischemia than those without it.This effect could not be blocked by propra-nolol-an adrenergic receptor antagonist.The effect of CGRP on CBF and heart rate in thepresent study and the possible mechanisms of increase of cerebral blood flow by CGRPwere discussed. |
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| Keywords: | Calcitonin gene-related peptide(CGRP) Cerebral ischemia Rats |
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