美托洛尔对充血性心力衰竭的治疗作用

①目的　观察美托洛尔对充血性心力衰竭 (CHF)的治疗效果。②方法　 6 2例CHF病人随机分为 2组 ,治疗组 32例 ,对照组 30例 ,两组均给予强心、利尿、扩血管治疗 ,治疗组在此基础上加用美托洛尔 ,维持治疗6 0d后判断疗效。③结果　治疗组心功能改善情况优于对照组 (uc=2 .0 5 ,P <0 .0 5 ) ,超声心动图检测心脏各功能参数以及心率、血压均较治疗前有明显改善 (t =2 .2 8～ 8.96 ,P <0 .0 5 ,0 .0 1) ,且变化较对照组明显 (t =2 .17～2 5 .75 ,P <0 .0 1)。有 5例出现轻微副作用。④结论　美托洛尔治疗CHF效果确切 ,但应用时需严密监测血压、心率、ECG变化 ,防止不良反应发生

EFFECT OF METOPROLOL IN CONGESTIVE HEART FAILURE

Objective\ To investigate the therapeutic outcome of Metoprolol on congestive heart failure(CHF). Methods\ Sixty two patients with CHF were divided randomly into Control group(30 patients) and Metoprolol group (32 patients). A regular treatment was given to all patients. For Metoprolol group, Metoprolol was added for 60 days and the efficacy was compared with that of the Control group. \ Results\ In Metoprolol group, the improvement of heart function was better than that of the Control group ( u c=2.05,P <0.05). Echocardiography showed remarkable improvement in the parameters of heart function, heart rate and blood pressure compared with those of before therapy ( t=2.28-8.96, P <0.05,0.01), and the changes were more obvious than that of the Control group ( t= 2.17- 25.75, P <0.01). Slight side effects were noted in 5 patients. Conclusion\ The efficacy of Metoprolol for patients with CHF is definite . The blood pressure, heart rate and electrocardiographic changes should be monitored for the side effects.