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| 氮酮和薄荷醇对联苯苄唑体外经皮渗透性的影响 | |
| 引用本文： | 刘焕龙,冯小龙,王新宇. 氮酮和薄荷醇对联苯苄唑体外经皮渗透性的影响[J]. 中国临床药理学与治疗学, 2004, 9(11): 1253-1255 |
| 作者姓名： | 刘焕龙 冯小龙 王新宇 |
| 作者单位： | 1. 河北医科大学第二医院药剂科,石家庄,050000,河北 2. 中奇制药技术(石家庄)有限公司药理室,石家庄,050051,河北 3. 华北制药康欣有限公司,石家庄,050017,河北 |
| 摘 要： | 目的：研究透皮促进剂氮酮和薄荷醇对外用抗真菌药联苯苄唑体外经皮渗透性影响。方法：在离体透皮实验装置上进行透皮吸收试验和贮库效应的研究，采用正交函数分光光度法消除皮肤浸出物的吸收干扰。结果：1％氮酮明显促进联苯苄唑经皮渗透作用，并可明显缩短时滞而增加贮库效应。结论：氮酮对亲脂性极强的药物联苯苄唑的促透皮吸收作用较强，而薄荷醇无明显的促透作用，但可增加贮库效应。 |
| 关 键 词： | 氮酮 薄荷醇 联苯苄唑 经皮渗透 正交函数分光光度法 |
| 文章编号： | 1009-2501(2004)11-1253-03 |
| 修稿时间： | 2004-08-25 |
Effects of 1-menthol and azone on percutaneous penetration of bifonazole in vitro |
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| LIU Huan-Long,FENG Xiao-Long,WANG Xin-Yu. Effects of 1-menthol and azone on percutaneous penetration of bifonazole in vitro[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(11): 1253-1255 | |
| Authors: | LIU Huan-Long FENG Xiao-Long WANG Xin-Yu |
| Affiliation: | LIU Huan-Long,FENG Xiao-Long,WANG Xin-YuDepartment of Pharmacy,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China , Department of Pharmacology,Zhongqi Pharmaceutical Technology CO.,LTD,Shijiazhuang 050051,Hebei,China , north China Pharmaceutical Kanxin Co.,LTD,Shijiazhuang 050017,Hebei,China |
| Abstract: | AIM: To investigate the effects of penetration enhancer 1-menthol and azone on percutaneous absorption of bifonazole in vitro. METHODS: Percutaneous penetration experiment was performed on device in vitro and deposit effect was observed by vivo perception. Orthogonal function spectrophotomery was used for obliterating the interferance of absorption RESULTS: Azone (1 %) had a significantly effect on percutaneous absorp-tion of bifonazole. The lag times were shortened and the deposit effect was increased by azone. CONCLUSION: Azone can enhance the percutaneous absorption of bifonazole. Menthol can not enhance the percutaneous absorption of bifonazole, but it can increase the deposit effect. |
| Keywords: | 1-menthol azone bifonazole percutaneous absorption orthogonal function spectrophotomery |
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