| 实验性慢性氟中毒大鼠致密胶原组织的光镜及电镜变化 |
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| 引用本文： | 肖开棋,曹序茂,于燕妮,邓传静,刘启兰,茹景顺,杨文庆,蒋功博,刘鲜林.实验性慢性氟中毒大鼠致密胶原组织的光镜及电镜变化[J].地方病通报,1989(2). |
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| 作者姓名： | 肖开棋 曹序茂 于燕妮 邓传静 刘启兰 茹景顺 杨文庆 蒋功博 刘鲜林 |
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| 作者单位： | 贵阳医学病理学教研室
(肖开棋，曹序茂，于燕妮，邓传静)，贵州省老年医学研究所
(刘启兰，茹景顺，蒋功博)，贵阳医学院电镜室
(杨文庆)，贵阳医学院电镜室(刘鲜林) |
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| 摘 要： | 本文观察了慢性氟中毒大鼠致密胶原组织——肌腱的光镜变化,发现肌腱内胶原组织成熟老化不够,胶原纤维较细,胶原蛋白形成较少。电镜改变则见胶原微纤维走行紊乱,粗细不均,甚至溶解断裂。对氟中毒时胶原纤维形态改变的机制及防治措施进行了讨论。
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| 关 键 词： | 慢性氟中毒 动物实验 致密胶原组织 肌腱 Wistar大鼠 光镜 电镜 病理学 |
LM AND EM STUDIES OF THE DENSE COLLAGENOUS TISSUE IN RATS WITH CHRONIC FLUOROSIS |
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| Xiao kai-qi,Cao Xu-mao,Yu Yan-ne,Deng Chuang-jing,Liu Qi-lan,Ru Jing-shun,Yang Wen-qing,Jiang Gong-bo,Liu Xian-lin.LM AND EM STUDIES OF THE DENSE COLLAGENOUS TISSUE IN RATS WITH CHRONIC FLUOROSIS[J].Endemic Diseases Bulletin,1989(2). |
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| Authors: | Xiao kai-qi Cao Xu-mao Yu Yan-ne Deng Chuang-jing Liu Qi-lan Ru Jing-shun Yang Wen-qing Jiang Gong-bo Liu Xian-lin |
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| Abstract: | LM and EM studies of the tendon in 21 rats with experimental chronic fluoride toxicosis were carried out.
LM study showed that the fibrils were thinner and the collagen was reduced. EM study showed that the microfibrils were disorganized, distorted and fragmented. These changes.are considered due to disturbance of the collagen concatenation resulted from depressed activity of the hydroxylase that was caused by decrease of ascorbic acid, hypoxia and reduced synthesis of collagen in case of fluorosis. |
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