2型糖尿病患者颈动脉硬化与超敏C反应蛋白关系的临床分析

目的]探讨C反应蛋白(CRP)与2型糖尿病患者颈动脉硬化的关系。方法]选择经颈动脉彩超检查的50例2型糖尿病合并颈动脉硬化患者作为病例组,50例单纯2型糖尿病患者作为对照组,均测定血清hsCRP,并分析与颈动脉内膜中层厚度、颈动脉粥样硬化斑块之间的相关性。结果]病例组血清hsCRP显著高于对照组。有颈动脉斑块的hsCRP显著高于颈动脉内中膜正常与增厚的hsCRP。结论]血清hsCRP与2型糖尿病患者颈动脉硬化的发生有关,CRP在2型糖尿病患者颈动脉硬化中起重要作用。

THE RELATIONSHIP BETWEEN C ACTIVE PROTEIN AND CAROTID ATHEROSCLEROSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Objective]To study the relationship between C active protein and carotid atherosclerosis in patients with type 2 diabetes mellitus.Methods]There were 2 groups in our study:50 type 2 diabetic patients with carotid atherosclerosis who were detected by colored doppler and 50 type 2 diabetic patients without carotid atherosclerosis.The concentration of serum hsCRP of all patients were determined by ELISA.The relationship between C active protein and the carotid intima to media thickness(IMT)as well as atheromatous plaque were analysed.Results]The level of serum hsCRP of carotid atherosclerosis group were significantly higher than that of control group.The level of serum hsCRP of the group with atheromatous plaque were significantly higher than that of the group whose IMT were normal or thicker.Conclusion]Elevated serum hsCRP may be one of probable risk factors in the carotid atherosclerosis in the patients with T2DM.