Specificity in mammalian peripheral nerve regeneration at the level of the nerve trunk |
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| Authors: | M.J. Politis |
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| Affiliation: | 1. Department of Fiber and Textile Processing Technology, Institute of Chemical Technology, Mumbai 400019, India;2. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India;1. Institute of Medical Sciences (S.J.B., A.S.G.), University of Toronto, Toronto, ON, Canada;2. ICES (S.J.B., R.K., L.P., A.S.G.), Toronto, ON, Canada;3. Sunnybrook Research Institute (S.J.B., A.V.L., R.S., L.P., A.S.G.), Sunnybrook Health Sciences Centre, Toronto, ON, Canada;4. Dalla Lana School of Public Health (R.S.), University of Toronto, Toronto, ON, Canada;5. Institute of Health Policy (L.P., ASG), Management and Evaluation, University of Toronto, Toronto, ON, Canada;6. School of Rehabilitation Sciences (D.B.), McMaster University, Hamilton, ON, Canada |
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| Abstract: | Previous studies indicate that distal stumps of transected rat peripheral nerves secrete 'tropic' factors which can attract/support axonal regeneration over distances of several mm in vivo. The present study was undertaken in order to determine if there is specificity of neurotropic interaction at the level of the nerve trunk. Proximal stumps of transected peroneal or tibial nerves were inserted into the single inlet end of Y-shaped Silastic implants and offered alternative 'lures' at the paired outlet ends (specifically, grafts of peroneal vs tibial distal stump tissue). Several weeks later, the overwhelming majority of preparations showed exclusive growth of nerve fibers in implant forks attached to 'native' (originally associated) nerve stumps. Inversion of the distal stump grafts (such that the proximal stump was facing an analogous native distal stump, but a different region of it) diminished the frequency and extent of native preference. Taken together, data suggest the possibility that there can be a specificity of nerve regeneration at the level of the nerve trunk. |
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| Keywords: | specificity nerve regeneration |
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