血清胆红素与不稳定型心绞痛的关系探讨

目的　探讨血清胆红素与不稳定型心绞痛 (UAP)发病的关系。方法　对符合 WHO U AP标准的 40 2例不稳定型心绞痛患者 (UAP组 )和 76 6例冠状动脉造影正常者 (对照组 )测定清晨空腹血清总胆红素浓度。比较两组间临床特征及实验室指标的差异 ,对血清总胆红素浓度与 U AP之间的关系进行单因素及多元逐步 L ogistic回归分析。结果　 U AP组血清总胆红素浓度显著低于对照组 (12 .7± 5 .2 μm ol/ L vs16 .0± 5 .7μmol/ L,P<0 .0 1) ;单因素分析显示血清总胆红素浓度越低 ,UAP发病率越高 (P<0 .0 1)。多元逐步 L ogistic回归发现 :血清总胆红素浓度与 U AP的发生显著负相关 (X2 wald =5 4.2 313,P=0 .0 0 0 1,OR=0 .899) ,血清总胆红素浓度减低是 U AP的独立危险因子。血清总胆红素浓度每减少一个等级 ,UAP的发病增加 10 .1%。结论　血清总胆红素浓度减低可能在UAP的发病中具有一定作用

The relationship between serum bilirubin and unstable angina pectoris

Objective To assess the relationship between serum bilirubin and unstable angina (UAP). Methods The clinical features and laboratory findings were reviewed in 402 patients with UAP (UAP group) and 766 patients with normal coronary arteries(control group).Univariate comparison and multiple logistic regression were applied to analyze the relationship between total serum bilirubin concentration and occurrence of UAP. Results The total serum bilirubin concentration was significantly lower in the UAP group than in the control group (12.7±5.2 μmol/L vs 16.0±5.7 μmol/L,P<0.01).Univariate analysis showed an inverse relationship between the serum bilirubin concentration and the morbidity of UAP (P<0.01). The multivariate logistic regression analysis indicated that a reduced total serum bilirubin concentration was an independent risk factor of UAP (χ 2wald =54.231 3,P=0.000 1,OR=0.899). A gradient decrease in total serum bilirubin concentration was associated with a 10.1% increase in the risk of UAP Conclusion Low total serum bilirubin concentration may play a role in the pathogenesis of UAP.