| 胎儿巩膜碱性成纤维细胞生长因子和转化生长因子β表达的研究 |
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| 引用本文： | 肖瑛,潘庆敏,高志娟,孙洪义,周亚滨,唐伟. 胎儿巩膜碱性成纤维细胞生长因子和转化生长因子β表达的研究[J]. 解剖学报, 2008, 39(1): 124-126 |
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| 作者姓名： | 肖瑛 潘庆敏 高志娟 孙洪义 周亚滨 唐伟 |
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| 作者单位： | 山东大学第二医院眼科,济南,250033;山东大学病原微生物研究所,济南,250012 |
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| 摘 要： | 目的 观察不同胎龄胎儿眼球巩膜碱性成纤维细胞生长因子(bFGF)和转化生长因子β(TGF-β)的表达情况,了解bFGF和TGF-β在正常眼球发育过程中的作用及变化规律.方法 收集12～20周米非司酮配伍米索前列醇或利凡诺羊膜腔注射引产的胎儿20例,其40只眼,立即摘除眼球,取4～5mm范围巩膜,用实时定量PCR方法检测巩膜bFGF和TGF-β的表达情况.结果 各胎龄阶段巩膜bFGF均有表达,胎龄12～14周时表达最高.以后逐渐下降并保持稳定水平,各胎龄阶段巩膜均有TGF-β表达,胎龄12周时表达较低,以后逐渐升高并保持稳定水平.结论 各胎龄阶段胎儿巩膜均有bFGF和TGF-β的表达,bFGF和TGF-β的表达水平随着胎龄的变化而变化.
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| 关 键 词： | 碱性成纤维细胞生长因子 转化生长因子β 后巩膜 实时定量PCR 胎儿 |
| 收稿时间： | 2007-01-25 |
| 修稿时间： | 2007-05-15 |
THE STUDY ON THE EXPRESSION OF BASIC FIBROBLAST GROWTH FACTOR AND TRANSFORMING GROWTH FACTOR-BETA IN THE SCLERA OF HUMAN FETUS |
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| XIAO Ying,PAN Qing-min,GAO Zhi-juan,SUN Hong-yi,ZHOU Ya-bin,TANG Wei. THE STUDY ON THE EXPRESSION OF BASIC FIBROBLAST GROWTH FACTOR AND TRANSFORMING GROWTH FACTOR-BETA IN THE SCLERA OF HUMAN FETUS[J]. Acta Anatomica Sinica, 2008, 39(1): 124-126 |
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| Authors: | XIAO Ying PAN Qing-min GAO Zhi-juan SUN Hong-yi ZHOU Ya-bin TANG Wei |
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| Affiliation: | P>1.Department of Ophthalmology，the Second Hospital of Shandong University, Ji’nan 250033,China; 2.Institute of Pathogenic Biology ,Shandong Univeisity, Ji’nan 250012,China/P> |
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| Abstract: | Objective To evaluate the existence of basic fibroblast growth factor(bFGF) and transforming growth factor beta(TGF-β)in the sclera in different fetal ages by real time polymerase chain reaction (PCR). Methods Forty human fetal eyes ranging in age from 12 to 20 pregnant weeks were carefully extracted. The sclera was carefully dissected. The expressions of bFGFand TGF-β were determined by real time PCR, and the results were analyzed comparatively. Results bFGF was expressed in the highest amount at the 12th to 14th pregnant week and decreased thereafter, while the expression of TGF-β lowered at the 12th week and increased gradually.Conclusion bFGF and TGF-β express in the sclera of the human fetal |
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| Keywords: | bFGF TGF-β Posterior sclera Real time PCR Human fetus |
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