草酸铂联合TNF腹腔内注射治疗胃肠道肿瘤所致腹水

目的：观察草酸铂（L-OHP）联合新型重组人肿瘤坏死因子（NrhTNF）腹腔内注射治疗恶性腹水的临床疗效、不良反应、对生存质量的影响。方法：20例晚期胃肠道肿瘤所致恶性腹水患者，（L-OHP）联合NrhTNF腹腔内注射，每周1次，连续2周。结果：20例患者无CR，PR55％（11／20），SD 35％（7／20）。主要不良反应为腹痛、发热、恶心，均较轻微。生活质量改善80％（16／20）。结论：（L-OHP）联合NrhTNF腹腔内注射治疗晚期胃肠道癌性腹水效果显著，不良反应轻微，可明显改善患者生存质量。

Effects of oxaliplatin combined with TNF by intraperitoneal perfusion for malignant ascites

Objective:To observe the clinical effects,side effects and influence on survival quality of oxaliplatin combined with new recombinant human tumor necrosis factor(NrhTNF) by intraperitoneal perfusion for malignant ascites. Methods:Twenty patients with malignant for malignant ascites. Methods:Twenty patients with malignant ascites caused by gastrointestinal tumor were treated with oxaliplatin combined with NrhTNF by intraperitoneal perfusion once a week for two weeks. Results:In twenty patients,there were no CR,but PR 55%(11/20),SD 35%(7/20). The major side effects were abdominal pain,fever and nausea,all of them were mild. The survival quality got improved in 80%(16/20) of patients. Conclusion:Intraperitoneal perfusion of oxaliplatin combined with NrhTNF had a good effect for malignant ascites caused by gastro-intestinal tumor with mild side effects,and could significantly improve the patients' survival quality.