慢性肺心病下呼吸道细菌感染菌种变迁及药敏分析

对比分析两个时期慢性肺心病下呼吸道感染的致病菌及其对抗菌药物的敏感状况。结果显示A组(1985～ 1990年 )革兰氏阳性球菌 (GPC)占 4 3.8% ,革兰氏阴性杆菌 (GNB)占 5 6 .2 % ;B组 (1995～ 2 0 0 0年 )GPC占 2 4 .6 % ,GNB占 75 .4 % ;A组致病菌主要为绿脓杆菌 (2 1.9% )、肺炎球菌 (18.8% )、链球菌 (10 .9% )、不动杆菌 (9.4 % )、表皮葡萄球菌 (7.8% )和克雷白杆菌 (7.8% ) ;B组则主要为绿脓杆菌 (30 .7% )、不动杆菌 (12 .3% )、表皮葡萄球菌 (12 .3% )、克雷白杆菌 (10 .5 % )、肠杆菌 (7.0 % )和金黄色葡萄球菌 (7.0 % )。提示 90年代以来致病菌以GNB为主 ,抗菌药物敏感性较 80年代大多有不同程度的下降 ,但目前常用的抗菌素仍然有效

Pathogen variance and drug-sensibility analysis of lower-respiratory- tract bacterial infection in chronic pulmonary heart disease

We contrastively analyzed pathogens and their drug sensibilities of lower respiratory tract infection in chronic pulmonary heart disease in two different periods. The results were that the Gram positive cocci (GPC) was 43.8% and Gram negative bacilli (GNB) was 56.2% in Group A (1985～1990); GPC was 24.6% and GNB was 75.4% in Group B (1995～2000). The predominant bacteria were in the following order: Preudomonas (21.9%), pneumococcal (18.8%), streptococcus (10.9%), acinetobacter (9.4%), staphylococcus epidermidis (7.8%), and klebsiella (7.8%)in Group A; and preudomonas (30.7%), acinetobacter (12.3%), staphylococcus epidermidis (12.3%), klebsiella (10.5%), enteric bacilli (7.0%), and staphylococcus aureus (7.0%) in Group B. The results suggest that GNB is the main pathogen in recent years; sensibility of most drugs in the 1990s fell in varying degrees compared with that in the 1980s, but antibacterial in common use is still available.