Heat-responsive gene expression for gene therapy |
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| Authors: | Wolfgang Walther Ulrike Stein |
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| Affiliation: | 3. From the Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033,;4. the Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany,;5. the PES Institute of Technology, Bangalore, India, and;6. the Laboratory of Structural Biology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892-8025;1. Department of Biochemistry, Chonnam National University Medical School, Gwangju 501-746, South Korea;2. Department of Biomedical Science and Chonnam National University Medical School, Gwangju 501-746, South Korea;3. Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, South Korea;4. Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo 519-763, South Korea;5. School of Integrative Engineering, Chung-Ang University, Dongjak-gu, Seoul 156-756, South Korea;6. BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Chonnam National University Medical School, Gwangju 501-746, South Korea;1. Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;2. Immunology Frontier Research Center at Osaka University, Osaka, Japan;3. Department of Endocrinology and Metabolism, Kyoto First Red Cross Hospital, Kyoto, Japan;4. Department of Endocrinology and Metabolism, Kyoto Second Red Cross Hospital, Kyoto, Japan;5. Department of Endocrinology and Metabolism, Osaka General Hospital of West Japan Railway Company, Osaka, Japan;6. Department of Cardiology, Nishijin Hospital, Kyoto, Japan;1. Department of Neurosurgery, Morsani College of Medicine, University of South Florida, 2 Tampa General Circle, 7th Floor, Tampa, FL 33606, USA;2. Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, 10945 Le Conte Avenue, Suite 2120, Los Angeles, CA 90095, USA;1. Cardiac Ultrasound Laboratory, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;2. Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;3. VIB Department for Molecular Biomedical Research, Ghent University, Ghent, Belgium |
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| Abstract: | Therapy-inducible vectors are useful for conditional expression of therapeutic genes in gene therapy, which is based on the control of gene expression by conventional treatment modalities. By this approach, combination of chemotherapy, radiation or hyperthermia with gene therapy can result in considerable, additive or synergistic improvement of therapeutic efficacy. This concept has been successfully tested in particular for gene therapy of cancer. The identification of efficient heat-responsive gene promoters provided the rationale for heat-regulated gene therapy. The objective of this review is to provide insights into the cellular mechanisms of heat-shock response, as prerequisite for therapeutic actions of hyperthermia and into the field of heat-responsive gene therapy. Furthermore, the major strategies of heat-responsive gene therapy systems in particular for cancer treatment are summarized. The developments for heat-responsive vector systems for in vitro and in vivo approaches are discussed. This review will provide an overview for this gene therapy strategy and its potential for multimodal therapeutic concepts in the clinic. |
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