Cough affects Quality of Life in asthmatic children aged 8-14 more than other asthma symptoms |
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| Authors: | Konstantinos Th Petsios Kostas N Priftis Constantinos Tsoumakas Aris Perperoglou Elpida Hatziagorou John N Tsanakas Ioannis Androulakis Vasiliki N Matziou |
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| Institution: | 1. Faculty of Nursing, National and Kapodistrian University of Athens, Greece;2. Department of Allergy-Pneumonology, Penteli Children''s Hospital, Greece;3. Department of Statistics and Actuarial-Financial Mathematics, Aegean University, Samos, Greece;4. Paediatric Respiratory Unit of the 3rd Paediatric Clinic of the Aristoteleio University, Hippokrateion General Hospital of Thessaloniki, Greece;3. Departments of Cell Physiology and Pharmacology, Leicester LE1 9HN, United Kingdom;4. Biochemistry, University of Leicester, Leicester LE1 9HN, United Kingdom;1. Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa;2. MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, South Africa;1. Division of Nephrology, Department of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand;2. Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;3. Pharmacokinetic Research Unit, Department of Pharmacology, Chulalongkorn University, Bangkok, Thailand;4. Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;5. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States;6. Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;1. Servicio de Cardiología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;2. Departamento de Bioquímica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;3. Servicio de Cardiología, Hospital Clínic i Provincial, Barcelona, Spain |
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| Abstract: | BackgroundAsthma may influence children's health-related quality of life (QoL) differently by various symptoms, at different severity. The primary aim of this study was to evaluate the QoL in children with asthma and describe the impact of each asthma symptom on the child's well-being at different severity levels.Material and MethodsTwo hundred randomly selected children and one of their parents who consulted an outpatient asthma clinic, participated in the study. Qol was assessed with DISABKIDS-Smiley measure for children aged 4-7 years and with DISABKIDS DCGM-37 and Asthma Module for children 8-14 year old.ResultsMost of the children suffered from mild or moderate persistent asthma. Children with uncontrolled asthma stated lower QoL compared to partly controlled or controlled in both age groups (p < 0.05 in all domains). Cough appeared to affect QoL of 8-14 year olds more than other symptoms, especially in girls. In younger children, sex (boys, p = 0.039), age (p = 0.045), proxy sex (father, p = 0.048), frequency of doctor visits (4-6 months, p = 0.001), use of beta-2 agonists (p = 0.007) and father's smoking habits (p = 0.015) were associated with the QoL of coughing children but no correlation between cough and QoL was detected. In the 8-14 year age group coughers reported lower QoL compared to their counterparts; moreover, cough was found to affect QoL more than other symptoms (p < 0.05 in all domains).ConclusionsCough has a direct effect on asthmatic children's QoL but there is still an obvious need for research to reveal all the determinats of this effect. |
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