| 血管紧张素转换酶基因多态性与动脉硬化性脑梗死的关系 |
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| 引用本文： | 陈登青,徐恩.血管紧张素转换酶基因多态性与动脉硬化性脑梗死的关系[J].新乡医学院学报,2007,24(5):465-467. |
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| 作者姓名： | 陈登青 徐恩 |
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| 作者单位： | 燕化凤凰医院神经内科; 广州医学院第二附属医院神经科学研究所 |
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| 摘 要： | 目的探讨血管紧张素转换酶(ACE)基因I/D多态性在脑梗死(CI)患者中的分布以及与CI的相互关系。方法CI组为临床确诊的CI患者150例,对照组90例为体检者,抽取DNA进行基因鉴定,并对2组进行比较。结果CI组ACE基因缺失型(DD)发生率(42.7%)明显高于对照组(24.4%,P<0.05),Logistic回归分析发现DD基因型的OR值达0.769。结论ACE基因缺失型(DD)与CI的关系密切,DD基因型是CI的危险因素。
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| 关 键 词： | 脑梗死 动脉硬化 血管紧张素转换酶 基因多态性 |
| 文章编号： | 1004-7239（2007）05-0465-03 |
| 收稿时间： | 2007-03-30 |
| 修稿时间： | 2007年3月30日 |
Relationship between angiotensin converting enzyme gene polymorphism and atherosclerotic cerebral infarction |
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| CHEN Deng-qing,XU En.Relationship between angiotensin converting enzyme gene polymorphism and atherosclerotic cerebral infarction[J].Journal of Xinxiang Medical College,2007,24(5):465-467. |
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| Authors: | CHEN Deng-qing XU En |
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| Institution: | 1. Department of Neurology, Yanhua Phoenix Hospital, Beijing 102500, China;2. Institute of Neuroscience , the Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, China |
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| Abstract: | Objective To explore the distribution of angiotensin converting enzyme gene I/D polymorphism in the patients with cerebral infarction(CI) and the relationship with CI.Methods 150 patients with CI and 90 healthy control subjects were carried out gene identification,and the results were compared.Results The incidence rate of the DD genotype in CI group was higher obviously than this in control group(42.7% and 24.4%,P<0.05).OR of DD genotype was 0.769.Conclusion The polymorphism of ACE gene DD is closely related with CI and it is a risk factor of CI. |
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| Keywords: | cerebral infarction atherosclerosis angiotensin converting enzyme gene polymorphism |
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