Antimycobacterial Activity and Mechanism of Action of NAS-91 |
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Authors: | Gratraud Paul Surolia Namita Besra Gurdyal S Surolia Avadhesha Kremer Laurent |
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Affiliation: | Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, CNRS, UMR 5235, case 107, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France. |
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Abstract: | The antimalarial agents NAS-91 and NAS-21 were found to express potent antimycobacterial activity, NAS-91 being more active than NAS-21. They partially inhibited mycolic acid biosynthesis and profoundly altered oleic acid production. The development of a cell-free assay for Delta 9-desaturase activity allowed direct demonstration of the inhibition of oleic acid biosynthesis by these compounds. |
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