| 八肽胆囊收缩素对大鼠滑膜细胞株RSC-364分泌IL-6的影响 |
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| 引用本文： | 赵占胜,金玉怀,徐锦荣,李淑瑾,于丹军,凌亦凌,丛斌. 八肽胆囊收缩素对大鼠滑膜细胞株RSC-364分泌IL-6的影响[J]. 基础医学与临床, 2003, 23(1): 85-88 |
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| 作者姓名： | 赵占胜 金玉怀 徐锦荣 李淑瑾 于丹军 凌亦凌 丛斌 |
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| 作者单位： | 河北医科大学病理生理学教研室,石家庄,050017 |
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| 摘 要： | 探讨八肽胆囊收缩素（CCK-8）对大鼠滑膜细胞株RSC-364分泌IL-6的调控作用。应用ELISA法观察不同浓度梯度的CCK-8对在TNF-α或IL-1β诱导下的RSC-364分泌IL-6水平的影响。结果显示：10^-6mol/L,10^-8mol/L浓度的CCK-8可分别促进TNF-α或IL-1β诱导24h后RSC-364细胞株分泌IL-6，而应用CCK受体拮抗剂丙谷胺则可明显抑制这种刺激效应，提示CCK-8可调节滑膜细胞分泌IL-6，在类风湿性关节炎的发病机制中可能起潜在的调控作用。
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| 关 键 词： | 胆囊收缩素 滑膜细胞 白细胞介素6 类风湿性关节炎 |
| 文章编号： | 1001-6325(2003)01-0085-04 |
| 修稿时间： | 2002-09-20 |
Effect of cholecystokinin octapeptide on IL-6 secretion by rat synovial cell line |
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| ZHAO Zhan sheng,JIN Yu huai,XU Jin rong,et al.. Effect of cholecystokinin octapeptide on IL-6 secretion by rat synovial cell line[J]. Basic Medical Sciences and Clinics, 2003, 23(1): 85-88 |
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| Authors: | ZHAO Zhan sheng JIN Yu huai XU Jin rong et al. |
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| Affiliation: | ZHAO Zhan sheng,JIN Yu huai,XU Jin rong,et al . |
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| Abstract: | To investigate the effect of cholecystokinin octapeptide(CCK 8) on the secretion of IL 6. The rat fibroblast like synovial cell line RSC 364 was stimulated with TNF. IL 1 and IL 6 concentration was measured by ELISA. The results showed that: CCK 8, at concentrations of 10 -6 mol/L and 10 -8 mol/L, significantly enhanced the production of IL 6 by this cell line after 24 hours of induction. The stimulating effect was inhibited by CCK 8 antagonist proglumide. These results suggested that:CCK 8 could regulate the IL 6 secretion by synoviocytes and may play a role in the pathogenesis of rheumatoid arthritis. |
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| Keywords: | cholecystokinin synoviocyte interleukin 6 rheumatoid arthritis |
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