网织血小板测定对特发性血小板减少性紫癜诊疗的价值

目的　探讨外周血网织血小板 (RP)变化对特发性血小板减少性紫癜 (ITP)的诊断价值及疗效判定。方法　利用流式细胞仪测定ITP(ITP组 )、再生障碍性贫血及白血病 (非ITP组 )及对照组外周血RP百分率 ,并计算其绝对值。结果　ITP组RP百分率明显高于非ITP组及对照组 (P <0 .0 1 ) ,绝对值明显低于对照组 (P <0 .0 1 ) ;非ITP组RP百分率与对照组比较无明显差异 (P >0 .0 5) ,但RP绝对值明显低于对照组 (P <0 .0 1 ) ;ITP组治疗有效者RP百分率明显降低 ,与治疗前比较差异显著 (P <0 .0 1 )。结论　RP百分率及绝对值可反映骨髓血小板生成情况 ,对血小板减少症发病机制判断具有重要意义 ,可作为血小板减少症鉴别诊断的重要指标 ,是确诊ITP诊断依据和疗效判定的监控指标。

Value of Reticulated Platelet Counts in Diagnosis and Treating Idiopathic Thrombocytopenic Purpura

Objective To evaluate the changes of reticulated platelets (RP)in diagnosis and treatment of idiopathic thrombocytopenic purpura (ITP). Methods RPs were measured by flow cytometry and the percentage and absolute counts of RPs were calcula- ted in ITP group,non-ITP group and control group.Results Compared with control group,ITP group had a significantly high percentage and low absolute counts of RPs (P<0.01). Compared with the cases with aplastic anemia and leukemia (non- ITP group), the percentage of RPs in ITP group increased significantly (P<0.01).There was no difference of RPs percentgae between non- ITP group and control group, but the absolute counts of RPs in non-ITP was significantly lower than that in control group (P<0.01).In ITP group the effective cases after treatment percentage of RPs had significantly lower than that before treatment (P<0.01).Conclusions The percentage and absolute counts of RPs reflect the state that megakaryocyte(MK) in bone marrow produce platelets. It is of important significance to identify the pathogenesis of thrombocytopeniam. It is also a valuable diagnostic method and a monitor mar- ker for ITP.