| 柴胡皂苷类化学成分的LC-MS分析 |
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| 引用本文： | 孙健,张立富,范斌,吕俊海. 柴胡皂苷类化学成分的LC-MS分析[J]. 中国药物警戒, 2012, 0(12): 725-727 |
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| 作者姓名： | 孙健 张立富 范斌 吕俊海 |
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| 作者单位： | [1]中国中医科学院医学实验中心,北京100700 [2]吉林大学公共卫生学院,吉林长春130021 |
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| 基金项目： | 中国中医科学院自主选题项目（ZZ2012004）;国家自然科学基金（81102672） |
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| 摘 要： | 目的建立柴胡皂苷类成分的LC-MS分析方法,研究柴胡皂苷类的化学成分。方法 60%乙醇回流提取柴胡;运用LC-MSn联用技术得到各化合物的总离子流图和多级质谱图,从而对各色谱峰进行鉴定。结果从柴胡提取物中鉴定出23个化合物。结论 HPLC-MSn法可用于柴胡中皂苷类成分的结构分析,为建立快速、准确的质量评价方法提供了参考。
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| 关 键 词： | 柴胡 皂苷类化学成分 成分分析 |
LC-MS Analysis of Saponins in Bupleurum Chinense DC. |
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| SUN Jian,ZHANG Li-fu,＇,FAN Bin,Lv Jun-hai. LC-MS Analysis of Saponins in Bupleurum Chinense DC.[J]. Chinese JOurnal of Pharmacovigilance, 2012, 0(12): 725-727 |
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| Authors: | SUN Jian ZHANG Li-fu ＇ FAN Bin Lv Jun-hai |
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| Affiliation: | 1Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China; 2Shoo1 of public health, Jilin University, Jilin Changchun 130021, China) |
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| Abstract: | Objective To study investigate the saponins in Bupleurum Chinense DC. by LC-MS. Methods The sample was extracted with 60% ethanol. The structures were detected by LC-MS experiments. Results 23 saponins were identified from Bupleurum Chinense DC. Conclusion This method can be used for rapid and accurate identification of saponins in Bupleurum chinense DC. |
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| Keywords: | Bupleurum Chinense DC saponins LC-MS |
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