血栓闭塞性脉管炎动物模型研究进展

目的对血栓闭塞性脉管炎(thromboangiitis obliterans TAO)动物模型制备方法进行综述,以寻找更加适合临床实际的造模方法。方法对近20年国内外TAO造模方法相关文献进行整理、分析、归纳。结果在已有TAO造模方法中,大鼠是首选造模动物,烟草致敏、寒冻、注射TAO免疫复合物等造摸方法虽然成模率都较好,也各有优缺点;以股动脉注射月桂酸改进模型与临床病理变化更相吻合,也被广泛应用于药理学活性发现和药效评价中。结论针对TAO发病机制的造模方法目前鲜有报道。因此,在深入探讨TAO发病机制基础上的造模方法学研究与模型制备,是创新药物发现与新药药效评价的前提。

Research Development on Animal Models of Thromboangiitis Obliterans

objective To summarize preparation methods of TAO in animals, and find a more suitable method of making model in clinical research. Methods The related references in recent 20 years both at home and abroad about model making methods of TAO were analyzed, collated and summarized. Results In all the methods, rats were the first selected animal, and the methods of tobacco sensitization, cold aspic, injecting immune complex of TAO were better for making models, but each method had its merits and demerits. Method of injecting lauric acid into atreira cruralis without ZT viscose final encapsulation was most related to the clinical pathological changes, and was widely used in the research on pharmacology activity and efficacy evaluation. Conclusion The research on model making methods related with pathogenesis of TAO was rarely reported. So the research on methodology of model making related with the pathogenesis of TAO should be explored deeply, and that was the premise in discovery of innovation drug and evaluation of new drug efficacy.