Comparative Nephrotoxicity of Gentamicin and Tobramycin in Rats |
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| Authors: | D N Gilbert C Plamp P Starr W M Bennett D C Houghton and G Porter |
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| Institution: | 1Leslie Gilbert Infectious Diseases Research Laboratory, Providence Medical Center, Portland, Oregon 97213;2Veterans Administration Hospital, Portland, Oregon 97207;3Department of Pathology,University of Oregon Health Sciences Center, Portland, Oregon 972014;4Department of Medicine University of Oregon Health Sciences Center, Portland, Oregon 97201 |
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| Abstract: | A rat model was utilized to compare the nephrotoxic potential of gentamicin and tobramycin. Gentamicin, 40 mg/kg per day, predictably produced renal failure and morphological evidence of proximal tubular necrosis over 14 days of treatment. An identical dosage of tobramycin was associated with only minimal morphological changes and normal concentrations of serum creatinine and blood urea nitrogen. Similar results were obtained even after the tobramycin dosage was tripled to 120 mg/kg per day. A decrease in urine osmolality, mechanism unknown, was observed in all aminoglycoside-treated rats, but the lowest osmolalities were found in the gentamicin-treated rats. According to both histological criteria and renal function measurements, gentamicin was more nephrotoxic than tobramycin in this animal model. |
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