善得定对门静脉高压性胃病大鼠胃粘膜灌注的影响

目的 观察善得定对门静脉高压性胃病（ｐｏｒｔａｌ ｈｙｐｅｒｔｅｎｓｉｖｅ ｇａｓｔｏｐａｔｈｙ，ＰＨＧ）大鼠胃粘膜血流最（ｇａｓｔｒｉｃ ｍｕｃｏｓａｌ ｂｌｏｏｄ ｆｏｗ，ＧＭＢＦ）的影响，并对其作用机制作初步探讨。方法 部分结扎大鼠门静脉主干２周后，观察善得定对ＰＨＧ大鼠全身血流动力学，ＧＭＢＦ，门静脉压力（ＰＶＰ）的影响，测定了输注善得定３０ｍｉｎ后ＰＨＧ大鼠血浆胰高糖素，血浆和胃粘膜ＮＯ

Effects of sandostatin on gastric mucosal perfusion in rats with portal hypertensive gastropathy

Objective To observe the effects of sandostatin on gastric mucosal blood flow(GMBF) in rats with (portal hypertensive gastropathy, PHG) and its mechanisms. Methods Two weeks after portal vein ligation, the changes of systemic hemodynamics, GMBF, (portal vein pressure, PVP) were observed and plasma glucagon, plasma and gastric mucosal NO2-/CO3 -, 6 - Keto- PGF 1 a were me asured after intravenons sandostati n, propranol of and norm al saline. Results GMBF and PVP were reduced after intravenous sandostatin or propranolol. Sadostatin decreased plasma glucagon, plasma and gastric mucosal NO2-I/NO3, and had no effect on MAP and heart rate of PHG rats as compared with control group of PHG. Propranolol had not these effects, but it might decrease MAP and heart rate. There were no differences of plasma and gastric mucosal 6-Keto-PGF1a. between all PHG groups. Conclusion Sandostatin reduced GMBF of rats with PHG by hindering glucagon, NO, and had no effect on systemic hemodynamics.