靶控输注不同浓度瑞芬太尼对视可尼喉镜气管插管丙泊酚EC50的影响

目的观察抑制视可尼喉镜气管插管反应,靶控输注不同浓度瑞芬太尼对丙泊酚半数有效浓度（EC50）的影响。方法择期全麻耳鼻喉科手术患者68例,ASA Ⅰ～Ⅱ级。依据瑞芬太尼靶浓度不同随机分为4组：RF1.5组,1.5ng/ml;RF2.0组,2.0ng/ml;RF2.5组,2.5ng/ml;RF3.0组,3.0ng/ml。同时靶控输注丙泊酚,以序贯法确定丙泊酚EC50,并计算95%可信区间。结果 RF1.5、RF2.0、RF2.5、RF3.0组视可尼喉镜插管无反应的丙泊酚EC50分别为3.62、3.38、2.90、2.69μg/ml。结论视可尼喉镜插管刺激强度小于传统喉镜,瑞芬太尼靶控浓度为2.0～2.5ng/ml时,丙泊酚EC50为3.38~2.90μg/ml,是较适宜的插管浓度。

Medium effective concentration of propofol required by Shikani tracheal intubation response in patients anesthetized with different concentrations of remifentanil by target controlled infusion

Objective To determine the medium effective concentration(EC50) of propofol based on the target controlled infusion(TCI) of remifentanil in the Shikani Optical Stylet(SOS) tracheal intubation.Methods Sixty-eight ASA Ⅰ～Ⅱ patients underwent ENT surgery were studied.Anesthesia induced both propofol and remifentanil given by TCI.The target effect concentration of remifentanil was set at 1.5、2.0、2.5、3.0 ng/ml.The EC50 of propofol was determined by up and down sequential trial.Results The EC50 of propofol was 3.62、3.38、2.90、2.69 μg/ml when remifentanil was 1.5、2.0、2.5、3.0 ng/ml.Conclusion The optimal target concentration for SOS intubation is 2.0～2.5 ng/ml for remifentanil and 3.38～2.90 μg/ml for EC50 of propofol.