| 新辅助化疗对乳腺癌细胞凋亡和增殖的影响 |
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| 引用本文： | 付晓艳,秦锡虎,陈同珏,谈敏.新辅助化疗对乳腺癌细胞凋亡和增殖的影响[J].蚌埠医学院学报,2006,31(6):624-626,F0003. |
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| 作者姓名： | 付晓艳 秦锡虎 陈同珏 谈敏 |
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| 作者单位： | 江苏省常州市妇幼保健院,乳腺科,213001;江苏省常州市第一人民医院肝胆外科,213001;江苏省常州市第一人民医院病理科,213001 |
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| 摘 要： | 目的:探讨新辅助化疗对乳腺癌肿瘤细胞的凋亡和增殖的影响.方法:应用末端脱氧核苷酸转移酶介导dUTP缺口末端标记法(TdT-mediated dUTP-biotin nick end labeling,TUNEL)及免疫组化的S-P法,分别检测新辅助化疗组和对照组乳腺癌组织中肿瘤细胞的凋亡指数(AI)和乳腺癌肿瘤组织的Ki-67抗原表达.结果:新辅助化疗组肿瘤细胞AI均数为9.26%,比对照组肿瘤细胞AI均数3.36%明显增高(P＜0.01).新辅助化疗组肿瘤细胞Ki-67抗原过表达率为15.63%,比对照组Ki-67抗原过表达率50.0%低(P＜0.05).结论:新辅助化疗能诱导人体乳腺癌肿瘤细胞发生凋亡,并能抑制其增殖.
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| 关 键 词： | 乳腺肿瘤 肿瘤/药物疗法 细胞凋亡 Ki-67抗原 |
| 文章编号： | 1000-2200（2006）06-0624-03 |
| 收稿时间： | 2006-02-28 |
| 修稿时间： | 2006-02-28 |
Influence of neoadjuvant chemotherapy on apoptosis and proliferation in patients with breast caner |
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| FU Xiao-yan,QIN Xi-hu,CHEN Tong-jue,TAN min.Influence of neoadjuvant chemotherapy on apoptosis and proliferation in patients with breast caner[J].Journal of Bengbu Medical College,2006,31(6):624-626,F0003. |
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| Authors: | FU Xiao-yan QIN Xi-hu CHEN Tong-jue TAN min |
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| Abstract: | Objective:To study the influence of neoadjuvant chemotherapy on tumor cell apoptosis and proliferation in patients with breast cancer.Methods:The apoptosis index(AI) of tumor cells in the neoadjuvant group and control group was assayed by TdT-mediated dUTP-biotin nick end labeling(TUNEL),and the Ki-67 antigen was examined by immunohistochemical method.Results:The AI of tumor cells was 9.26 in the neoadjuvant group and 3.36 in the control group.The difference was significant(P<0.01).The overexpression rate of Ki-67 antigen in the neoadjuvant group was 15.63,which was 50.0 lower than that in the control group(P< 0.05). Conclusions:Neoadjuvant chemotherapy can induce tumor cell apoptosis and inhibit tumor cell proliferation in patients with breast cancer. |
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| Keywords: | breast neoplasms neoplasms/drug otherapy apoptosis Ki-67 antigen |
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