FAP-1和RAC-1在原发性胰腺癌组织中的表达及其临床意义

目的探讨Fas相关磷酸酯酶1（FAP-1）和RAC-1在原发性胰腺癌中的表达及其与胰腺癌侵袭转移之间的关系。方法应用免疫组化SP技术，检测40例原发性胰腺癌组织中FAP-1和RAC-1的表达，分析其与胰腺癌侵袭转移之间关系。结果胰腺癌组织中FAP-1和RAC-1的表达明显高于胰腺正常组织（P〈0．01），且两者存在相关性（P〈0．05），同时FAP-1和RAC-1的表达有淋巴结转移表达明显高于无淋巴结转移组（P〈0．05）。FAP-1和RAC-1阳性表达与胰腺癌病理组织学分类无相关性（P〉0．05）。结论FAP-1和RAC-1的表达能反映原发性胰腺癌的侵袭转移能力，联合检测两种蛋白的表达对诊断胰腺癌具有一定临床意义。

Expressions of FAP-1 and RAC-1 in primary pancreatic cancer and their clinical significances

Objective To investigate the expressions of fas-associated phophatase-1 （ FAP-1 ） and ras-related C3 botulinum toxin substraee-1 （ RAC-1 ） in primary pancreatic cancer （PPC） and their associations with the metastasis of PGC. Methods The expressions of FAP-1 and RAC-1 in PPC tissues （n = 40） were detected by immunohistochemistry. The relationship between the expressions and the invasion and metastasis of PPC was analyzed. Results The expressions of FAP-1 and RAC-1 in PPC were significantly higher than those in normal pancreatic tissue （P 〈 0.01 ） and the expressions of RAC-1 were correlated with those of FAP-1 （P 〈 0.05）. The expressions of FAP-1 and RAC-1 were significantly higher in lymph node metastasis than those without lymph node metastasis （P 〈 0.05 ）. There was no correlation between the positive expressions of FAP-1 and RAC-1 and the histopathological classification in pancreatic cancer （P 〉 0. 05 ）. Conclusion The expressions of FAP-1 and RAC-1 in PPC may reflect the metastasis of PPC and joint detection of the expressions of two proteins is of certain clinical significance in the diagnosis of pancreatic cancer.