异氟醚对成年大鼠行为学的影响

目的探讨国产异氟醚（宁芬）对成年大鼠学习记忆功能的影响。方法成年雄性SD大鼠36只（n=6×6组），将其随机分为空白对照组（A组）、阳性对照组（02组）、麻醉组。三组大鼠进行Morris水迷宫定位航行适应性训练5d，记录逃避潜伏期和总路程。麻醉组吸人2．0％浓度国产异氟醚30min，苏醒后2h、1d、7d、14d再次行水迷宫实验，观察指标与适应性训练相同。结果麻醉30min呼吸次数明显减少；与第1天比较，第2,3、4,5天逃避潜伏期、总路程差异显著（P〈0．01），且随着天数的增加逐渐缩短。结论大鼠吸入宁芬30min后，1d内对学习记忆有一定程度影响，1d后学习记忆逐渐改善，自行恢复到麻醉前水平。

Effect of domestic isoflurane induced cognitive dysfunction on adult rats

Objective To explore the effect of domestic isoflurane （Ningfen） induced learning and memory dysfunction on adult rats. Methods 36 （n = 6 × 6）adult male Spragne Dawley rats were randomly divided into 6 groups, control group（ group air）, positive control group （group 02 ）,anesthesia group （4 subgroups were divided as inhalation of domestic isoflurane）. SD rats in anesthesia groups were given 2% isoflurane, recorded breath rate of the preanesthesia,anesthetized for 30rain, then repeat the test again after 2 h, 1 d,7 d, 14 d recover time re- spectively. Results Compared with group 1 d after anesthesia,the escape latency and path length of group 2 d,3 d,4 d and 5 d after anesthesia have shown significantly statistical differences （ P 〈 0. 01 ）, shortened as time passing on. Conclusion The inhalation of domestic isoflurane （Ningfen） after 1 d might affect the special memorizing ability of SD rats,however,after ld of post anesthesia recovery,such ability can i~e re- stored completely to the original level.