Graves眼病患者血清中自身抗体水平检测及临床意义

目的探讨Graves眼病患者血清中自身抗体水平检测及临床意义。方法选取2018年1月至2020年5月周口市中心医院Graves眼病患者83例作为观察组,其中非浸润性突眼48例,浸润性突眼35例,同期选取单纯Graves患者64例作为对照Ⅰ组、健康体检者52例作为对照Ⅱ组。均检测甲状腺功能[游离三碘甲状腺原氨酸(FT₃)、游离甲状腺素(FT₄)]、血清自身抗体[促甲状腺激素受体抗体(TRAb)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)]水平,比较三组及观察组不同病情患者上述血清学指标,分析临床价值。结果不同分组间血清FT₃、FT₄、TRAb、TPOAb、TgAb水平经单因素方差分析,差异有统计学意义(P<0.05);观察组、对照Ⅰ组血清FT₃、FT₄、TRAb、TPOAb、TgAb水平高于对照Ⅱ组(P<0.05);浸润性突眼患者血清TRAb、TPOAb、TgAb水平高于非浸润性突眼患者(P<0.05);经Pearson相关系数模型分析,血清TRAb、TPOAb、TgAb水平与血清FT₃、FT₄水平间无相关性(P>0.05);经Spearman相关系数模型分析,血清TRAb、TPOAb、TgAb水平与病情间呈正相关(P<0.05)。结论血清自身抗体水平在Graves眼病患者中显著升高,且升高程度高于单纯Graves患者,可能参与Graves眼病发生发展过程,可为临床完善治疗方案提供参考。

Detection and clinical significance of serum autoantibodies in patients with Graves ophthalmopathy

【Objective】To investigate the detection of serum autoantibodies in patients with Graves ophthalmopathy and its clinical significance.【Methods】Eighty-three patients with Graves'ophthalmopathy in our hospital from January 2018 to May 2020 were selected as the observation group,including 48 cases of non-invasive exophthalmos and 35 cases of invasive exophthalmos.Sixty-four cases of Graves'ophthalmopathy were selected as control group I and 52 cases of healthy persons as control group II.The levels of thyroid function[free triiodothyronine(FT₃),free thyroxine(FT₄)],serum autoantibodies[thyroid stimulating hormone receptor antibody(TRAb),thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TgAb)]were detected.The above serological indexes were compared between the three groups and the observation group,and the clinical value was analyzed.【Results】The serum levels of FT₃,FT₄,TRAb,TPOAb and TgAb between different groups were statistically different(P<0.05).The levels of FT₃,FT₄,TRAb,TPOAb and TgAb in observation group and control group I were higher than those in control group II(P<0.05).The levels of TRAb,TPOAb and TgAb in patients with invasive exophthalmos were higher than those in patients with non-invasive exophthalmos(P<0.05).Pearson correlation coefficient model analysis showed that there was no correlation between serum TRAb,TPOAb,TgAb levels and serum FT₃,FT₄ levels(P>0.05).Spearman correlation coefficient model analysis showed that serum TRAb,TPOAb,TgAb levels were positively correlated with the disease(P<0.05).【Conclusion】The level of serum autoantibodies in patients with Graves'ophthalmopathy is significantly higher than that in patients with Graves'disease,which may be involved in the occurrence and development of Graves'ophthalmopathy,and can provide reference for clinical treatment.