110例胆道闭锁患儿临床资料分析

目的回顾性分析110例胆道闭锁患儿的临床特征以为胆道闭锁的诊断和治疗提供更多证据。方法收集2017年8月至2020年8月期间在深圳市儿童医院收治的110例胆道闭锁患儿的临床资料,对患儿的一般资料和实验室检查资料进行总结分析。结果本研究纳入的110例胆道闭锁患儿中,男49例(39%),女67例(61%)。在所有患儿中仅有4例为早产儿;87例(79%)患儿出现白陶土样便;30例(28%)患儿的γ-谷氨酰转肽酶(γ-GT)<300 u/L,79例(72%)患儿的γ-GT≥300 u/L。比较γ-GT<300 u/L组和γ-GT≥300 u/L组两组患儿的临床特征,发现γ-GT<300 u/L组的ALT和AST水平均显著高于γ-GT≥300 u/L组(P<0.05)。巨细胞病毒病原学检查发现13例患儿呈阳性。结论本研究发现胆道闭锁多见于足月儿,且伴有持续性黄疸及白陶土样大便,多数患儿的γ-GT高于300 u/L。

Clinical characteristics of 110 infants with biliary atresia

【Objective】To retrospectively analyze the clinical characteristics of 110 infants with biliary atresia to provide more evidence for the diagnosis and treatment of biliary atresia.【Methods】The clinical characteristics of 110 infants with biliary atresia admitted to Shenzhen Children's Hospital from August 2017 to August 2020 were collected.The general data and laboratory examination data of the infants were analyzed.【Results】Among the 110 infants,49(39%)and 67(61%)were male and female,respectively.Only 4 of all infants were premature infants.Eighty-seven(79%)infants had white clay-like stools.Thirty(28%)infants had γ-GT<300 u/L,and 79(72%)infants had γ-GT≥300 u/L.By comparing the clinical characteristics of the γ-GT<300 u/L group and the γ-GT≥300 u/L group,the ALT and AST levels in the γ-GT<300 u/L group were significantly higher than those in the γ-GT≥300 u/L group(P<0.05).Thirteen cases of infants had cytomegalovirus infection.【Conclusion】This study found that biliary atresia is more common in full-term infants with persistent jaundice,white clay-like stools,and γ-GT≥300 u/L.