| 降酶保肝合剂对四氯化碳致大鼠急性肝损伤的防治作用 |
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| 引用本文： | 昌兰芳,刘昌. 降酶保肝合剂对四氯化碳致大鼠急性肝损伤的防治作用[J]. 时珍国医国药, 2004, 15(4): 217-218 |
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| 作者姓名： | 昌兰芳 刘昌 |
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| 作者单位： | 1. 湖北中医学院,湖北,武汉,430061
2. 武汉大学人民医院药学部,湖北,武汉,430060 |
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| 摘 要： | 目的：观察降酶保肝合剂对CCl4皮下注射致大鼠急性肝损伤的防治作用。方法：采用大鼠皮下注射CCl4造成大鼠急性肝损伤模型并于造模前、后灌胃给药。结果：该剂能改善CCl4致急性肝损伤模型大鼠血清ALT、AST和SOD、MDA、GSH指标；对肝细胞病变有一定程度的保护作用。结论：降酶保肝合剂抗肝损伤的作用与其降酶、清除活性氧自由基、抗脂质过氧化反应有关。
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| 关 键 词： | 降酶保肝合剂 肝损伤 抗脂质过氧化反应 |
| 文章编号： | 1008-0805(2004)04-0217-01 |
| 修稿时间： | 2003-12-01 |
The Protective Effects of Jiang Mei Bao Gan Mixture on Liver Injured by CCl4 |
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| CHANG Lan-fang,LIU Chang. The Protective Effects of Jiang Mei Bao Gan Mixture on Liver Injured by CCl4[J]. Lishizhen Medicine and Materia Medica Research, 2004, 15(4): 217-218 |
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| Authors: | CHANG Lan-fang LIU Chang |
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| Affiliation: | CHANG Lan-fang~1,LIU Chang~2 |
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| Abstract: | Objective: To investigate the protective effects of Jiang Mei Bao Gan Mixture on acute liver injury. Methods: Liver injury model was employed by injection of carbon tetrachloride (CCl_4). Results: The results suggested that Jiang Mei Bao Gan mixture could decrease ALT, AST activities and MDA content, and improve SOD, GSH activities in serum. It could lessen steatois degree. Conclusion: Jiang Mei Bao Gan Mixtrue had the marked effects of preventing liver injury, which related to its effects of decreasing ALT, AST activities and anti-lipid peroxidation in liver injury. |
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| Keywords: | Jiang Zhi Bao Gan Mixture Liver injury Anti-lipid peroxidation |
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