Concentraciones de interleucina-18 en preeclámpticas y embarazadas normotensas sanas |
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Authors: | Eduardo Reyna-Villasmil Jorly Mejia-MontillaNadia Reyna-Villasmil Duly Torres-CepedaJoel Santos-Bolívar Jhoan Aragón-Charris |
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Institution: | Servicio de Obstetricia y Ginecología, Maternidad Dr. Nerio Belloso, Hospital Central Dr. Urquinaona, Maracaibo, Estado Zulia, Venezuela |
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Abstract: | ObjectiveTo compare concentrations of interleukin-18 in pre-eclampsia patients and healthy normotensive pregnant women.MethodA total of 100 patients were selected. Fifty pre-eclamptic patients were selected as cases (group A) and a control group selected by having the same age and body mass index to study group, consisting of 50 healthy normotensive pregnant women. Blood samples were collected in all patients before labour and immediately after diagnosis in group B to determine interleukin-18 concentrations.ResultsThere were no significant differences in relation to maternal age, gestation age and body mass index at the time of taking the sample (P = ns). There was a statistically significant difference in interleukin-18 concentrations between patients in cases group (group A; 38.6 ± 6.5 pg/ml) and patients in control group (group B; 32.2 ± 8.5 pg/ml; P < .05). There was a moderate, positive and significant correlation with systolic blood pressure values (r = 0.341; P < .05) and with diastolic blood pressure values (r = 0.408; P < .05).ConclusionsPre-eclampsia patients had significantly higher concentrations of interleukin-18 when compared with healthy normotensive pregnant women. |
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Keywords: | Interleucina-18 Preeclampsia Embarazo |
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