Therapeutic effect of hyperbaric oxygen on 32 cases of magraine

Background:Clinical manifestation of magraine is periodical onset of fluctuating headache caused by dysfunction of nerve-vessel,which mechanism is still unclear.Objective: To evaluate therapeutic effect of hyperbaric oxygen on magraine.Unit:Central Hospital of Jinzhou City.Subjects: According to diagnosis standards formulated by 1998 International Headache association,64 cases magraine in neural department of central hospital of Jinzhou city were randomly divided into 2 groups.Treatment group:12 males,20 females,aged 18-50 (mean:34)years old with disease course 4 months to 20 years (mean:4.5 years).Control group:13 males,19 females,aged 16-48(mean:33)years old with disease course 3 months to 18 years(mean:5 years).There was no obvious difference at sex,age,conditon between 2 groups.Intervention:Control group:Buflomedil was used,0.1g,once a day,venous injection and 14 days as a therapeutic course.Control group:On base of drug therapy,hyperbaric oxygen chamber therapy was adopted,raising pressure for 30-35min,stabilized pressure for 40 min,reducing pressure for 20 min,therapy pressure 0.2 MPa,once a day,10 days as a therapeutic course.Main prognosis index:Control:no relapse of headache when treating;Marked:Headache alleviated,continuing time shortened obviously,onset times reduced over 60%;Effective:Headache alleveated and continuing time shortened,onset times reduced over 50%;Ineffective:above standards couldn‘t be achieved.Result: Comparison of therapeutic effects between two groups see table 1.Conclusion: Both combination of hyperbaric oxygen with drug and simple drug therapy could reduce onset frequency of magraine,but combination therapy was more effective,and could shorten effect-producing time.

Therapeutic effect of hyperbaric oxygen on 32 cases of magraine

Background:Secondary head injury following severe head trauma is a main factor affecting prognosis,treatment for which is an effective measure in improving prognosis.It is indicated that hyperbaric oxygen can facilitate recovery of injured nerve cells.Objective:To investigate effect of hyperbaric oxygen plus naloxone in the treatment of severe head trauma.Unit:Daping Hospital,Third Military Medical University.Subjects:During February 1999 to December 2001,50 patients suffered from head trauma aged 11-60 years were randomly divided into two groups,treatment group (hyperbaric oxygen plus naloxone beyond routine management) and control group(routing treatment),each group having 25 patients.Injury causes included traffic accidents(n=17),and falling injury(n=8).there were no significant difference in age,sex,and injury causes between the two groups.Severe head injury was confirmed at admission with GCS score varying between 3-8(P&;gt;0.05).GCS score was used to evaluate patients before and after treatment.GCS and KPS behavior evaluation was performed 3-6 months after discharge.Intervention:Routine treatment consisted of craniotomy(n=17),antiinfection,maintenance of water and electrolyte balance and decompression of intracerebral pressure for extensive axon injury,and neuroactivator management.10 cases was dead (40%),5 showed favorable rehabilitation (20%),3 suffered from moderate disability (12%),5 from severe disability,2 lived a vegetarian life (8%).Comatose lasted for 14 days averagely.In treatment group,16 accepted craniotomy,and 9 suffered from extensive axon injury.Treatment groups received hyperbaric oxygen plus naloxone beyond routine treatment.Patients undergoing surgery were treated 48 hours without operation received hyperbaric oxygen 24 hours after admission.Method:Patients were placed in a large Hyperbaric oxygen cabin and oxygen was given for 35min&;#215;2.0 xygen was given with mask or head mask under 0.2 MPa and an interval of 10 min.Pressure increase and decrease lasted for about 45 min,once a day.10 days was a treatment course.5-2 treatment course were adopted in our study.8mg naloxone was administered during hyperbaric oxygen treatment,once a day.Result:7 cases were dead(28%),12 showed good recovery (48%),4 suffered from moderate disability (16%),2 from severe disability (8%).Comatose time lasted for about 9 days for all patients.Conclusion:Hyperbasic oxygen plus naloxone can decrease mortality,disability rate,and rehabilitation duration after severe head trauma.