细胞周期蛋白G2在喉癌中的表达

目的探讨细胞周期蛋白G2(Cyclin G2)的表达与喉鳞状细胞癌的关系。方法收集2000年1月～2000年12月共81例喉鳞状细胞癌患者的临床资料和石蜡块,用免疫组化方法检测肿瘤组织、喉癌旁黏膜Cyclin G2表达:并分析Cyclin G2的表达与喉癌患者年龄、性别、临床分期、肿瘤分化程度以及预后等的关系。统计学分析采用SPSS12.0软件。结果Cyclin G2在喉癌中阳性表达率为67.9%,并随分化程度的降低而降低,有、无淋巴结转移者阳性率分别为38.4%和73.5%,差异均具有显著性(P>0.05)。结论Cyclin G2表达强度与喉癌的恶性程度及发展趋势明显负相关,可作为预测喉癌预后的生物学指标之一。

Expression and its significance of Cyclin G2 in laryngeal squamous cell carcinoma

OBJECTIVE To study the correlation between the expression level of Cyclin G2 and the laryngeal squamous cell carcinoma.METHODS The clinical data and paraffin-embedded tumor samples of 81 patients with LSCC treated at Shenyang 463 Hospital between Jan. 2000 to Dec.2000 were retrieved.Cyclin G2 expression was analyzed immunohistochemically in tumor tissues and adjacent normal laryngeal mucosa.The relationship between Cyclin G2 expression and clinical data including age,gender,tumor stage,pathological type,and prognosis were analyzed using software SPSS12.0.RESULTS The positive rate of Cyclin G2 in laryngeal squamous cell carcinomas was 66.7% and it was correlated with tumor differentiation,lymph node metastasis(both P value less than 0.05).CONCLUSION The expression of CyclinG2 correlates with the malignant degree and development tendency of LSCC negatively.Cyclin G2 is an important biological factor affecting the prognosis.