CD45分子结构和功能研究进展

CD45分子是第一个被确认的典型的受体型蛋白酪氨酸磷酸酶(RPTPα),儿乎在所有的有核白细胞表面均有表达.在环境信号整合进入细胞并引起反应的过程中,蛋白激酶和磷酸酶共同调节的酪氨酸磷酸化状态是一个关键的调控点,CD45分子在酪氨酸的磷酸化过程中发挥重要作用.CD45突变细胞系、CD45缺陷小鼠、CD45缺陷人群的研究均表明了CD45对于抗原受体信号转导和淋巴细胞的分化发育等过程都是必不可少的,CD45分子功能紊乱会导致自身免疫性疾病、免疫缺陷、恶性肿瘤等.

Study advance in molecular structure and function of CD45

CD45 is the first and prototypic receptor-like protein tyrosine phosphatase and is expressed on allnucleated hematopoietic cells. Regulation of tyrosine phosphorylatiou is a critical control point for the integrationof environmental signals into cellular responses. This regulation is mediated by the reciprocal actions of proteintyrosine kinases and phosphatases. CD45 plays a central role in this process. Studies on CD45 mutant celllines, CD45-deficient mice, and CD45-deficient humans initially demonstrated the essential role of CD45 in an± iger receptor signal transduction and lymphocyte development. Perturbation of this function may result in au-toimmune, immunodeficieney, and malignant diseases.